A Study of Nivolumab in Advanced Non-Small Cell Lung Cancer (NSCLC)



Status:Active, not recruiting
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:5/4/2018
Start Date:November 13, 2015
End Date:April 15, 2019

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A Master Protocol of Phase 1/2 Studies of Nivolumab in Advanced NSCLC Using Nivolumab as Maintenance After Induction Chemotherapy or as First-line Treatment Alone or in Combination With Standard of Care Therapies (CheckMate 370: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 370)

The purpose of this study is to determine whether nivolumab monotherapy or in combination
with Standard of care (SOC) therapies will provide clinical benefit (i.e., PFS, OS, and DOR)
without unacceptable toxicity in advanced Non-Small Cell Lung Cancer patients.

Epidermal Growth Factor Receptor (EGFR), Anaplastic Lymphoma Kinase (ALK)

**Please note that the study is no longer enrolling patients for Groups A, B, C, and E.

For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com

Inclusion Criteria:

- Histologically confirmed locally advanced or stage IV NSCLC

- Eastern Cooperative Oncology Group (ECOG) Performance status (PS) 0-2

- Tumor tissue sections must be available for biomarker evaluation

Exclusion Criteria:

- Untreated or active/progressing Central Nervous system (CNS) metastases

- Active, known or suspected autoimmune disease

- Known history of testing positive for HIV or AIDS

- Active or chronic infection of hepatitis B virus or hepatitis C
We found this trial at
134
sites
500 North 8th Street
Bismarck, North Dakota 58501
1010
mi
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Bismarck, ND
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3551 Roger Brooke Dr
Fort Sam Houston, Texas 78234
(210) 916-4141
Brooke Army Medical Center Brooke Army Medical Center (BAMC) is the Flagship of Army Medicine!...
1786
mi
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Fort Sam Houston, TX
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Gainesville, Florida 32611
2450
mi
from 98109
Gainesville, FL
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3700 Johnson Street
Hollywood, Florida 33021
Phone: 954-844-6898
2720
mi
from 98109
Hollywood, FL
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433 Southwest 10th Street
Ocala, Florida 34471
Phone: 353-732-4032
2483
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from 98109
Ocala, FL
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1871 SE Tiffany Ave # 100
Port Saint Lucie, Florida 34952
2654
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Port Saint Lucie, FL
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Abilene, Texas 79606
Phone: 325-692-0188
1582
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Abilene, TX
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Albany, New York 12206
Phone: 518-262-6696
2351
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from 98109
Albany, NY
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3330 Masonic Dr
Alexandria, Louisiana 71301
1934
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from 98109
Alexandria, LA
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1200 S Cedar Crest Blvd
Allentown, Pennsylvania 18103
(610) 402-8000
Lehigh Valley Hospital At Lehigh Valley Health Network, we continually go the extra mile to...
2337
mi
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Allentown, PA
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Amarillo, Texas 79106
Phone: 806-358-8654
1356
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Amarillo, TX
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Anderson, Indiana 46011
1879
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Anderson, IN
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Annapolis, Maryland 21401
Phone: 443-481-4390
2343
mi
from 98109
Annapolis, MD
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Arlington, Texas 76012
Phone: 817-664-9600
1668
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from 98109
Arlington, TX
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Athens, Georgia 30607
Phone: 706-353-2990
2209
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Athens, GA
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Bakersfield, California 93309
Phone: 661-616-1619
865
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Bakersfield, CA
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Baltimore, Maryland 20742
(301) 405-1000
Phone: 410-328-8708
University of Maryland As a globally-connected university offering a world-class education, the University of Maryland...
2327
mi
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Baltimore, MD
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2401 W Belvedere Ave
Baltimore, Maryland 21215
(410) 601-9000
Sinai Hospital of Baltimore Sinai Hospital of Baltimore provides a broad array of high-quality, cost-effective...
2323
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Baltimore, MD
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Beaumont, Texas 77702
Phone: 409-899-7180
1924
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Beaumont, TX
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Bedford, Texas 76022
Phone: 817-359-9033
1664
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Bedford, TX
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6410 Rockledge Dr #660
Bethesda, Maryland 20817
(301) 571-0019
Phone: 301-571-2016
Center for Cancer & Blood Disorders Widely recognized for its compassionate, expert care, the Center...
2314
mi
from 98109
Bethesda, MD
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Bethlehem, Pennsylvania 18015
2178
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Bethlehem, PA
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Billings, Montana 59102
Phone: 406-238-6290
667
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Billings, MT
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Birmingham, Alabama 35223
Phone: 205-803-4389
2080
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Birmingham, AL
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Blacksburg, Virginia 24060
Phone: 540-381-5291
2254
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Blacksburg, VA
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Bridgeton, Missouri 63044
1704
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Bridgeton, MO
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Charleston, South Carolina 29403
Phone: 843-577-6957
2422
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from 98109
Charleston, SC
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Chattanooga, Tennessee 37404
Phone: 423-698-1844
2085
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Chattanooga, TN
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5053 Wooster Rd
Cincinnati, Ohio 45226
(513) 751-2273
Phone: 859-727-2273
Oncology Hematology Care Our more than 60 physicians and advanced practice providers throughout neighborhood offices...
1969
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Cincinnati, OH
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2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
2020
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Cleveland, OH
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2024
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Cleveland, OH
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Columbia, Maryland 21044
Phone: 410-581-2100
2318
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Columbia, MD
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2008
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Columbus, OH
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Dallas, Texas 75246
Phone: 214-370-1000
1681
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Dallas, TX
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Dallas, Texas 75237
Phone: 214-943-9911
1683
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Dallas, TX
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Dallas, Texas 75246
1681
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Dallas, TX
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Denton, Texas 76210
1651
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Denton, TX
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Easton, Maryland 21601
2371
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Easton, MD
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Edina, Minnesota 55435
Phone: 612-884-6300
1390
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Edina, MN
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El Paso, Texas 79902
Phone: 915-544-6750
1377
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El Paso, TX
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Erie, Pennsylvania 16505
Phone: 814-838-9000
2073
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Erie, PA
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Eugene, Oregon 97401
Phone: 541-683-5001
249
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Eugene, OR
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1717 13th St
Everett, Washington 98201
(425) 297-5500
Phone: 425-297-5500
Providence Regional Cancer Partnership Founded in 2007, the Providence Regional Cancer Partnership is the result...
25
mi
from 98109
Everett, WA
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Phone: 703-208-3173
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
2313
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Fairfax, VA
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Farmington, New Mexico 87401
1047
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Farmington, NM
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Flemington, New Jersey 08822
2369
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Flemington, NJ
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Flower Mound, Texas 75028
Phone: 972-537-4100
1656
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Flower Mound, TX
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Fort Myers, Florida 33916
Phone: 239-274-9930
2618
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Fort Myers, FL
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Fort Wayne, Indiana 46845
1870
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Fort Wayne, IN
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Fort Worth, Texas 76104
Phone: 817-850-2000
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Fort Worth, TX
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Fort Worth, Texas 76104
Phone: 817-759-7023
1661
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Fort Worth, TX
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Fullerton, California 92835
Phone: 714-446-5804
978
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Fullerton, CA
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Germantown, Tennessee 38138
Phone: 901-685-5969
1877
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Germantown, TN
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Germantown, Tennessee 38138
Phone: 901-683-0055
1877
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Germantown, TN
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Glens Falls, New York 12801
2339
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Glens Falls, NY
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Grand Junction, Colorado 81501
Phone: 970-298-7500
908
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Grand Junction, CO
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1796
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Grand Rapids, MI
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501 N. Elam Avenue
Greensboro, North Carolina 27403
336-832-1100
Phone: 336-832-0836
Cone Health Cancer Center Located adjacent to Wesley Long Hospital, our Cone Health Cancer Center...
2297
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from 98109
Greensboro, NC
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501 N. Elam Avenue
Greensboro, North Carolina 27403
336-832-1100
Cone Health Cancer Center Located adjacent to Wesley Long Hospital, our Cone Health Cancer Center...
2297
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Greensboro, NC
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Greensboro, North Carolina
2297
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Greensboro, NC
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373 North Fayetteville Street
Greensboro, North Carolina 27403
2310
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Greensboro, NC
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Greenville, South Carolina 29615
Phone: 864-455-7773
2225
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Greenville, SC
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Hattiesburg, Mississippi 39401
Phone: 601-288-8282
2067
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Hattiesburg, MS
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Houston, Texas 77024
Phone: 713-467-1722
1884
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Houston, TX
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Houston, Texas 77030
1892
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Houston, TX
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Huntington, West Virginia 25701
2088
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Huntington, WV
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Irving, Texas 75063
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Irving, TX
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Jackson, Mississippi 39202
Phone: 601-974-5547
1983
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Jackson, MS
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Johnson City, New York 13790
Phone: 607-763-6850
2267
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Johnson City, NY
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La Jolla, California 92037
1056
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La Jolla, CA
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Lakewood, Colorado 80228
Phone: 303-430-2700
1015
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Lakewood, CO
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9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
878
mi
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Las Vegas, NV
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Lincoln, Nebraska 68510
Phone: 402-327-7363
1348
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Lincoln, NE
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Los Angeles, California 90095
Phone: 310-267-5964
959
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Los Angeles, CA
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Medford, Oregon 97504
Phone: 541-774-5853
367
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Medford, OR
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Mesquite, Texas 75150
Phone: 972-686-6411
1685
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Mesquite, TX
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Metairie, Louisiana 70006
2092
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Metairie, LA
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Miami, Florida 33176
Phone: 305-595-2141
2731
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Miami, FL
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Midland, Texas 79701
Phone: 432-688-0843
1515
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Midland, TX
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Mobile, Alabama 36608
Phone: 251-607-5281
2145
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Mobile, AL
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Morristown, New Jersey 07960
2377
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Morristown, NJ
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Mount Kisco, New York 10549
2398
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Mount Kisco, NY
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
1908
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Nashville, TN
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New Braunfels, Texas 78130
Phone: 210-595-5300
1786
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New Braunfels, TX
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2400
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New York, NY
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Newnan, Georgia 30265
2176
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Newnan, GA
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Niles, Illinois 60714
Phone: 847-827-9060
1721
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Niles, IL
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5900 Lake Wright Dr
Norfolk, Virginia 23502
(757) 466-8683
Phone: 757-466-8683
Virginia Oncology Associates Virginia Oncology Associates is an oncology and hematology practice of physicians, specializing...
2434
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Norfolk, VA
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Norwich, Connecticut 06360
2465
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Norwich, CT
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2393
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Nyack, NY
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Omaha, Nebraska 68114
Phone: 402-393-3110
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Omaha, NE
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Paducah, Kentucky 42003
1852
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Paducah, KY
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Paris, Texas 75460
Phone: 972-537-4100
1690
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Paris, TX
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Paris, Texas 75460
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Paris, TX
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Phoenix, Arizona 85016
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Phoenix, AZ
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Pinehurst, North Carolina 28374
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Pinehurst, NC
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Plano, Texas 75075
1673
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Plano, TX
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Plano, Texas 75093
Phone: 972-596-7801
1667
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Plano, TX
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Richmond, Virginia 23235
Phone: 804-288-7159
2346
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Richmond, VA
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Saint Petersburg, Florida 33705
Phone: 727-216-1143
2529
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Saint Petersburg, FL
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Salisbury, North Carolina 28144
Phone: 704-638-9000
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Salisbury, NC
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