Non-invasive Measurement of Cerebral Dynamic Autoregulation
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 50 - Any |
| Updated: | 8/4/2018 |
| Start Date: | June 2015 |
| End Date: | June 2020 |
| Contact: | Kim Gannon, M.D |
| Email: | kimberly.gannon@uphs.upenn.edu |
The overall objective of this study is to evaluate the use of diffuse correlation
spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with
vascular risk factors. Optical cerebral blood flow measurements will be correlated with
changes in arterial blood pressure to assess how CBF is maintained in response to changes in
ABP, and will be compared to transcranial doppler reference measurements.
spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with
vascular risk factors. Optical cerebral blood flow measurements will be correlated with
changes in arterial blood pressure to assess how CBF is maintained in response to changes in
ABP, and will be compared to transcranial doppler reference measurements.
Inclusion Criteria:
- Age greater than or equal to 50 years
- Positive history of at least one of the following vascular disk factors: hypertension,
diabetes, hyperlipidemia, coronary artery disease, atrial fibrillation, prior
myocardial infarct, transient ischemic attack, or history of smoking
Exclusion Criteria:
- Vascular risk factor subjects:
1. Pregnant women
2. Prisoners
3. Prior neurosurgical procedure or traumatic brain injury, including
hemicraniectomy or other skull defect
4. Prior history of ischemic or hemorrhagic stroke
5. Prior lower extremity amputation
6. Peripheral vascular disease
We found this trial at
1
site
3400 Spruce St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-4000
Phone: 215-662-2700
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
Click here to add this to my saved trials
