Evaluation of Efficay & Safety of Galcanezumab in the Prevention of Episodic Migraine- the EVOLVE-2 Study



Status:Completed
Conditions:Migraine Headaches
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 65
Updated:1/9/2019
Start Date:December 4, 2015
End Date:October 5, 2018

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A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 in Patients With Episodic Migraine - the EVOLVE-2 Study

The main purpose of this study is to evaluate the efficacy and safety of the study drug known
as galcanezumab in participants with episodic migraine.


Inclusion Criteria:

- Have a diagnosis of migraine as defined by International Headache Society (IHS)
International Classification of Headache Disorders (ICHD)-3 beta version (1.1 or 1.2)
(ICHD-3 2013), with a history of migraine headaches of at least 1 year prior to
screening, migraine onset prior to age 50 and MONTHLY frequency of 4-14 MHD.

Exclusion Criteria:

- Are currently enrolled in or have participated within the last 30 days or within 5
half-lives (whichever is longer) in a clinical trial involving an investigational
product.

- Current use or prior exposure to galcanezumab or another Calcitonin Gene-Related
Peptide (CGRP) antibody.

- Known hypersensitivity to multiple drugs, monoclonal antibodies or other therapeutic
proteins, or to galcanezumab.

- History of persistent daily headache, cluster headache or migraine subtypes including
hemiplegic (sporadic or familial) migraine, ophthalmoplegic migraine, and migraine
with brainstem aura (basilar-type migraine) defined by IHS ICHD-3 beta.
We found this trial at
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Farmington Hills, Michigan 48334
Principal Investigator: Aaron Ellenbogen
Phone: 248-957-8940
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Steven Graff-Radford
Phone: 310-423-9616
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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1709 S Rock Rd
Wichita, Kansas 67207
316-689-6629
Principal Investigator: Timothy Koehler
Phone: 316-462-0426
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Akron, Ohio 44320
Principal Investigator: Jose Rafecas
Phone: 330-572-1011
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Albuquerque, New Mexico
Principal Investigator: Marigene Sharma
Phone: 505-224-7407
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Apple Valley, California 92307
Principal Investigator: JienSup Kim
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811 Juniper St NE
Atlanta, Georgia 30308
(404) 881-5800
Principal Investigator: Robert Riesenberg
Phone: 404-881-5800
Atlanta Center for Medical Research Welcome to the Atlanta Center for Medical Research, a leader...
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Bellevue, Washington 98007
Principal Investigator: Arifulla Khan
Phone: 425-453-0404
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Binghamton, New York 13760
Principal Investigator: DUNCAN SZE-TU
Phone: 607-754-3863
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Brooklyn, New York 11235
Principal Investigator: Nicholas Vatakis
Phone: 708-616-2230
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Centennial, Colorado 80112
Principal Investigator: Itay Melamed
Phone: 303-771-9000
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Champaign, Illinois 61820
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Chicago, Illinois 60614
Principal Investigator: Alexander Feoktistov
Phone: 773-388-6390
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Cincinnati, Ohio 45267
Principal Investigator: Lesley Arnold
Phone: 513-558-4622
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Columbus, Ohio 43214
Principal Investigator: Jeffrey White
Phone: 614-263-4400
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801 Monterey Street
Coral Gables, Florida 33134
Principal Investigator: Jeffrey Rosen
Phone: 305-445-5637
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Dallas, Texas 75231
Principal Investigator: Michael Downing
Phone: 214-369-2600
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Dayton, Ohio 45432
Principal Investigator: Steve Choi
Phone: 937-912-4367
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Greer, South Carolina 29651
Principal Investigator: Thomas Ballard
Phone: 864-334-0141
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Hazelwood, Missouri 63042
Principal Investigator: Larry Reed
Phone: 314-972-9600
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High Point, North Carolina 27265
Principal Investigator: Margarita Nunez
Phone: 336-841-0700
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Hollywood, Florida 33021
Principal Investigator: Harvey Schwartz
Phone: 954-366-0277
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Houston, Texas 77074
Principal Investigator: Alan Reichman
Phone: 713-484-6947
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Indianapolis, Indiana 46256
Principal Investigator: KRISTI GEORGE
Phone: 317-537-6060
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Jacksonville, Florida 32205
Principal Investigator: Herman Downey
Phone: 904-693-1490
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Jacksonville, Florida 32216
Principal Investigator: Nandita Joshi
Phone: 904-281-5757
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Las Vegas, Nevada 89113
Principal Investigator: Abraham Nagy
Phone: 702-749-7147
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Middleton, Wisconsin 53562
Principal Investigator: RISE FUTTERER
Phone: 608-827-2316
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Montclair, California 91763
Principal Investigator: Mia Moon
Phone: 909-203-4706
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Mount Pleasant, South Carolina 29464
Principal Investigator: Cynthia Strout
Phone: 843-856-3784
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New Bedford, Massachusetts 02740
Principal Investigator: Mushtaque Chachar
Phone: 508-990-9555
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Newport News, Virginia 23606
Principal Investigator: Chester Fisher
Phone: 757-591-8100
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Oakland, California 94612
Principal Investigator: Ira Glick
Phone: 510-444-2877
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Ocoee, Florida 34761
Principal Investigator: Kelly Taylor
Phone: 407-654-2724
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Oklahoma City, Oklahoma 73103
Principal Investigator: Louise Thurman
Phone: 405-235-8188
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Philadelphia, Pennsylvania 19114
Principal Investigator: Eugene Andruczyk
Phone: 215-676-6696
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Phoenix, Arizona 85004
Principal Investigator: Joshua Tobin
Phone: 602-265-6500
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Phoenix, Arizona 85023
Principal Investigator: Louise Taber
Phone: 623-414-4022
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Salt Lake City, Utah 84109
Principal Investigator: Dan Henry
Phone: 801-486-3021
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San Diego, California 92108
Principal Investigator: William Koltun
Phone: 619-521-2830
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San Francisco, California 94102
Principal Investigator: Shawn Hassler
Phone: 415-423-4055
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Seattle, Washington 98122
Principal Investigator: Braden Nago
Phone: 206-860-4761
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Sherman Oaks, California 91403
Principal Investigator: Jose Itzcovich-Schuster
Phone: 818-788-0746
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South Jordan, Utah 84095
Principal Investigator: Katie Julien
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Springfield, Oregon 97477
Principal Investigator: Miguel Estevez
Phone: 541-868-9430
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Tampa, Florida
Principal Investigator: Cynthia Huffman
Phone: 813-877-8839
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Toms River, New Jersey 08755
Principal Investigator: Ashok Patel
Phone: 732-244-2299
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Virginia Beach, Virginia 23456
Principal Investigator: Amelito Malapira
Phone: 757-507-0607
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Waxahachie, Texas 75165
Principal Investigator: Thomas Ledbetter
Phone: 972-961-3949
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