Answer ALS: Individualized Initiative for ALS Discovery



Status:Active, not recruiting
Conditions:Healthy Studies, Neurology
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:18 - 100
Updated:2/7/2019
Start Date:December 2015
End Date:January 2020

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Answer ALS -Creation of a Large Bio-repository of iPS Cells, Cell Lines, and Bio-fluid Samples, Combined With Clinical Information to Rapidly Advance Therapeutics That Could Treat ALS

Creation of a large repository of induced pluripotent stem cells (iPSC), bio-fluid samples
(blood and spinal fluid (optional)), and cell lines for ALS gene identification. This will be
combined carefully with collected measures of the pattern of the symptoms people with ALS
have and how these change over time. People with other motor neuron diseases and healthy
controls will be included as comparisons

Patients will have 5 study visits; screening, 3, 6, 9 and 12 months. There will be a one year
post-participation follow-up period, during which they will receive an email or phone call
interview once every 3 months. During the first year, samples will be collected, breathing,
muscle strength, spasticity, general function and cognitive behavior will be assessed.
Healthy controls will have 2 study visits during which blood samples will be collected and
questionnaires given.

Inclusion Criteria:

- Participants with familial or sporadic ALS diagnosed as possible, laboratory-supported
probable, probable or definite according to the World Federation of Neurology (WFN) El
Escorial criteria, Primary Lateral Sclerosis Flail Arm ALS, Progressive Muscular
Atrophy, Monomelic Amyotrophy, Motor Neuron Disease, Asymptomatic ALS Gene Carriers

- Participants who are ages 18-100, inclusive.

Exclusion Criteria:

- Participants with Spinal-Bulbar Muscular Atrophy

- Known diagnosis of HIV/AIDS, Hepatitis B, or Hepatitis C.
We found this trial at
8
sites
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: James D Berry, MD
Phone: 617-726-4284
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Principal Investigator: Jonathan Glass, MD
Phone: 404-727-1273
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Atlanta, GA
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Phone: 410-502-0495
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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Baltimore, MD
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Robert H. Baloh, MD, PhD
Phone: 424-315-2694
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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Los Angeles, CA
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303 E Chicago Ave
Chicago, Illinois 60611
(312) 503-8194
Phone: 312-503-7504
Northwestern University Feinberg School of Medicine Northwestern University Feinberg School of Medicine, founded in 1859,...
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Chicago, IL
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410 W 10th Ave
Columbus, Ohio 43210
(614) 293-8652
Principal Investigator: Stephen J Kolb, MD, PhD
Phone: 614-688-7837
The Ohio State University, Wexner Medical Center Located in Columbus, The Ohio State University Wexner...
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Columbus, OH
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Dallas, Texas 75214
Principal Investigator: Daragh Heitzman, MD
Phone: 214-827-3610
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Dallas, TX
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Timothy Miller, MD
Phone: 314-747-7881
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Saint Louis, MO
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