Exercise in Genetic Cardiovascular Conditions

Yale is the central site for this multicenter study. Patients with HCM and LQTS will be
recruited via high-volume HCM and LQTS sites, patient-groups, and websites. Information about
exercise participation will be acquired via interview and online instruments at enrollment
and every six months for three years. Quality of Life questionnaires will be filled out at
enrollment and at the end of the study. Participants will receive a Fitbit (pedometer) and
will wear it initially for two weeks and then one week every three months. The Fitbit is used
for assessment of exercise level only. Clinical records will be obtained from treating
physicians. Participants will also be asked to call the central site if they experience
syncope, appropriate ICD (implantable cardioverter defibrillator) shock, or resuscitated
arrest. Information regarding the patient's activity at the time of event will then be
obtained by phone interview. Follow-up clinical records will be obtained as indicated to
corroborate endpoints.

Inclusion Criteria:

- Individuals with Hypertrophic Cardiomyopathy or Long QT Syndrome

Exclusion Criteria:

- Individuals with Hypertrophic Cardiomyopathy with systolic or diastolic heart failure
which precludes vigorous exercise will not be enrolled (NYHA III/IV)