DECAMP-2: Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer



Status:Recruiting
Conditions:Lung Cancer, Pulmonary
Therapuetic Areas:Oncology, Pulmonary / Respiratory Diseases
Healthy:No
Age Range:50 - 79
Updated:11/1/2018
Start Date:September 2011
End Date:December 2019
Contact:Ehab Billatos, MD
Email:ebillato@bu.edu
Phone:617-358-7039

Use our guide to learn which trials are right for you!

Detection of Early Lung Cancer Among Military Personnel Study 2 (DECAMP-2): Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer

The goal of this project is to improve lung cancer screening in high-risk individuals by
identifying biomarkers of preclinical disease and disease risk that are measured in minimally
invasive and non-invasive biospecimens. Existing biomarkers for lung cancer diagnosis as well
as new biomarkers discovered specifically in this clinical setting will be examined.
Biomarkers that identify individuals at highest risk for being diagnosed with lung cancer
prior to the appearance of concerning symptoms could increase the utility of lung cancer
surveillance and the efficiency of lung cancer chemoprevention clinical trials. Achieving
these goals would improve the detection and treatment of early stage and incipient lung
cancer, while restricting the risk of these procedures to those individuals who currently
exhibit the early molecular warning signs of impending disease.

The Detection of Early lung Cancer Among Military Personnel (DECAMP) consortium is a
multidisciplinary and translational research program that includes 7 Veterans Administration
Hospitals (VAH), the 4 designated Military Treatment Facilities (MTF) and 4 academic
hospitals as clinical study sites, several molecular biomarker laboratories, along with
Biostatics, Bioinformatics, Pathology and Biorepository cores. The DECAMP Coordinating Center
will facilitate rapid selection, design and execution of clinical studies within this
multi-institutional consortium. The ACRIN 4704 study will recruit one cohort to achieve the
aims of this study: a longitudinal screening cohort.

Inclusion Criteria for longitudinal screening cohort

- Ages 50 to 79 years;

- Smoking status: Current or former smoker (≥10 cigarettes/day for current smokers, or
≥20 pack years for former smoker who quit 20 years ago or less)

- History of Chronic Obstructive Pulmonary Disease (COPD), emphysema, or at least one
first-degree relative with a diagnosis of lung cancer;

- Willing to undergo fiberoptic bronchoscopy;

- Able to tolerate all biospecimen collection as required by protocol;

- Able to comply with standard-of-care follow-up visits, including clinical exams,
diagnostic work-ups, and imaging for a maximum of four years or until diagnosis of
lung cancer;

- Able to fill out Patient Lung History questionnaire;

- Willing and able to provide a written informed consent.

Exclusion Criteria

- Diagnosis of lung cancer prior to the current assessment (that is, patients are
eligible if first lung cancer diagnosis has been recently confirmed by bronchoscopic
biopsy and is leading to resection surgery, but not if this is not a first diagnosis);

- Contraindications to nasal brushing or fiberoptic bronchoscopy, including: ulcerative
nasal disease, hemodynamic instability, severe obstructive airway disease (i.e.,
disease severity does not allow for bronchoscopic procedures), unstable cardiac or
pulmonary disease, as well as other comorbidities leading to inability to protect
airway, or altered level of consciousness;

- Allergies to any local anesthetic that may be used to obtain biosamples in the study;

- Weight greater than that allowable by the CT scanner.
We found this trial at
15
sites
Buffalo, New York
Principal Investigator: Mary Reid, PhD
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
620 John Paul Jones Cir
Portsmouth, Virginia 23708
(757) 953-5008
Principal Investigator: Jonas Carmichael, MD
Naval Medical Center - Portsmouth Naval Medical Center Portsmouth, Virginia has proudly served the military...
?
mi
from
Portsmouth, VA
Click here to add this to my saved trials
34800 Bob Wilson Dr,
San Diego, California 92134
(619) 532-6400
Principal Investigator: John S Parrish, MD
Naval Medical Center - San Diego We are the largest and most comprehensive military healthcare...
?
mi
from
San Diego, CA
Click here to add this to my saved trials
8901 Rockville Pike
Bethesda, Maryland 20889
(301) 295-4000
Principal Investigator: Robert Browning, MD
Walter Reed National Military Medical Center The Walter Reed National Military Medical Center is one...
?
mi
from
Bethesda, MD
Click here to add this to my saved trials
Boston, Massachusetts
Principal Investigator: Ronald Goldstein, MD
?
mi
from
Boston, MA
Click here to add this to my saved trials
1 Boston Medical Center Place
Boston, Massachusetts 02118
617.638.8000
Principal Investigator: Ehab Billatos, MD
Boston University Medical Center Boston Medical Center is an extraordinary community of health care providers...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Dallas, Texas
Principal Investigator: John Battaile, MD
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Denver, Colorado
Principal Investigator: Robert Keith, MD
?
mi
from
Denver, CO
Click here to add this to my saved trials
Los Angeles, California
Principal Investigator: Steven Dubinett, MD
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Los Angeles, California 90024
Principal Investigator: Steve Dubinett, MD
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Nashville, Tennessee
Principal Investigator: Pierre Massion, MD
?
mi
from
Nashville, TN
Click here to add this to my saved trials
3900 Woodland Avenue
Philadelphia, Pennsylvania 19104
Principal Investigator: Anil Vachani
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Principal Investigator: Anil Vachani, MD
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Pittsburgh, Pennsylvania 15240
Principal Investigator: Charles Atwood, MD
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
San Antonio, Texas
Principal Investigator: Michael Morris, MD
?
mi
from
San Antonio, TX
Click here to add this to my saved trials