A Study of LY2951742 in Participants With Episodic Cluster Headache



Status:Completed
Conditions:Migraine Headaches
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 65
Updated:7/15/2018
Start Date:May 2015
End Date:June 4, 2018

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A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 in Patients With Episodic Cluster Headache

The main purpose of this study is to evaluate the efficacy and safety of the study drug known
as LY2951742 in participants with episodic cluster headaches.


Inclusion Criteria:

- Participants with a history of episodic cluster headache with at least two cluster
periods lasting from 7 days to 1 year (when untreated) and separated by pain-free
remission periods of ≥1 month.

- Participants are able to distinguish cluster headache attacks from other headaches.

Exclusion Criteria:

- Current enrollment in or discontinuation within the last 30 days from, a clinical
trial involving any investigational drug or device.

- Current use or any prior exposure to any calcitonin-gene-related peptide (CGRP)
antibody, any antibody to the CGRP receptor, or antibody to nerve growth factor (NGF).

- Are taking indomethacin and/or are suspected of having another distinct trigeminal
autonomic cephalalgia.

- A history of migraine variants that could implicate or could be confused with
ischemia.

- Known hypersensitivity to multiple drugs, monoclonal antibodies or other therapeutic
proteins.

- A history or presence of other medical illness that indicates a medical problem that
would preclude study participation.

- Evidence of significant active or unstable psychiatric disease, in the opinion of the
investigator.

- Women who are pregnant or nursing.
We found this trial at
18
sites
1 Tampa General Cir
Tampa, Florida 33606
(813) 844-7000
Principal Investigator: Kavita Kalidas
Phone: 813-844-7900
Tampa General Hospital In a diverse city known for its rich culture and beautiful beaches,...
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Alan Newman
Phone: 310-423-9563
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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Miami, Florida 33124
(305) 284-2211
Principal Investigator: Teshamae Monteith
Phone: 305-243-4069
University of Miami A private research university with more than 15,000 students from around the...
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Amherst, New York 14226
Principal Investigator: Laszlo Mechtler
Phone: 716-558-5670
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Ann Arbor, Michigan 48104
Principal Investigator: Joel Saper
Phone: 734-677-6000
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811 Juniper St NE
Atlanta, Georgia 30308
(404) 881-5800
Principal Investigator: Robert Riesenberg
Phone: 404-881-5800
Atlanta Center for Medical Research Welcome to the Atlanta Center for Medical Research, a leader...
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Bellevue, Washington 98007
Principal Investigator: Arifulla Khan
Phone: 425-453-0404
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Charleston, South Carolina 29406
Principal Investigator: David Stickler
Phone: 843-725-5067
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Englewood, Colorado
Principal Investigator: Cori Millen
Phone: 720-336-4300
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Gent,
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Jacksonville, Florida 32216
Principal Investigator: Todd Rozen
Phone: 904-953-2209
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Morgantown, West Virginia
Principal Investigator: David Watson
Phone: 304-598-6127
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Palo Alto, California 94305
Principal Investigator: Nada Hindiyeh
Phone: 650-497-6810
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1020 Walnut St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Principal Investigator: Stephen Silberstein
Phone: 215-955-2072
Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...
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1200 7th Ave N
Saint Petersburg, Florida 33705
Principal Investigator: Michael Franklin
Phone: 727-820-7701
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Santa Monica, California 90404
Principal Investigator: David Kudrow
Phone: 310-315-1456
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Springfield, Missouri 65807
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Stamford, Connecticut 06905
Principal Investigator: Peter McAllister
Phone: 203-914-1903
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