Simple Bone Cysts in Kids



Status:Recruiting
Conditions:Orthopedic
Therapuetic Areas:Orthopedics / Podiatry
Healthy:No
Age Range:2 - 21
Updated:11/16/2018
Start Date:March 2015
End Date:March 2022
Contact:Brittany Barnes
Email:brittany.barnes@sickkids.ca
Phone:416-813-7654

Use our guide to learn which trials are right for you!

Simple Bone Cysts in Kids (SBoCK)

Simple bone cysts (SBCs) are cysts filled with fluid that occur most frequently in the long
bones (arms or legs) of children. There are many ways to treat SBCs but it is unclear if one
is better than another. The purpose of this research trial is to compare the effectiveness of
two common treatments that are used by surgeons today.

In general, few randomized clinical trials have been undertaken in paediatric orthopaedics,
and only one to date has addressed the problem of simple bone cysts (SBCs). Also known as
unicameral bone cysts, they are the commonest bone lesion in children. Despite general
opinion, these cysts do not resolve at skeletal maturity.

Many forms of treatment have been recommended but none, including the popular methods of
corticosteroid or bone marrow injections, have reliably eradicated SBC. Although the lesions
are considered benign (non-cancerous), they cause pain, frequently interfere with function,
dramatically restrict play activity, may re-fracture leading to growth arrest and/or
deformity, and cause enormous anxiety for children and their families.

With a well-developed network of surgeons and researchers, we will provide evidence comparing
the effectiveness of two treatment interventions for SBC. More specifically, our goals for
this study are:

1. to compare the rate of radiographic healing between two standard treatments including
curettage with puncture alone, and curettage with puncture followed by injection with
Vitoss morsels;

2. to identify prognostic radiographic factors associated with simple bone cyst healing and
fracture;

3. to determine the impact of simple bone cyst on children/family functioning.

Inclusion Criteria:

- Patients with a confirmed simple bone cyst in a long bone (ie. arm or leg) within last
3 months

- At least 3 weeks must have elapsed since last fracture

- At least 3 months must have elapsed since last cyst treatment

- Patients and/or their legal representatives willing to provide written informed
consent (and assent, when appropriate)

- Patients with stabilizing implants in the bone where the cyst is located

Exclusion Criteria:

- Patients with bone disease (ie. osteogenesis imperfecta, cancer, osteoporosis, Paget's
disease)

- Pregnant or breastfeeding female

- Patients with cysts crossing the growth plate (area where bone grows)
We found this trial at
12
sites
New York, New York
Principal Investigator: David Godfried
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New York, NY
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1600 7th Avenue
Birmingham, Alabama 35233
(205) 638-9100
Principal Investigator: Shawn R Gilbert
Children's Hospital of Alabama Children
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Birmingham, AL
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Chapel Hill, North Carolina 27599
(919) 962-2211
Principal Investigator: Anna Vergun
University of North Carolina at Chapel Hill Carolina’s vibrant people and programs attest to the...
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Chapel Hill, NC
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
Principal Investigator: Joel Sorger
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
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Cincinnati, OH
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Baltimore, Maryland 21287
Principal Investigator: Jay Lee
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from
Baltimore, MD
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Bronx, New York 10467
Principal Investigator: Jacob F Schulz
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from
Bronx, NY
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Calgary, Alberta
Principal Investigator: Elaine Joughin
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from
Calgary,
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225 E Chicago Ave
Chicago, Illinois 60611
(312) 227-4000
Principal Investigator: Joseph A Janicki
Ann & Robert H. Lurie Children's Hospital of Chicago Ann & Robert H. Lurie Children
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from
Chicago, IL
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6621 Fannin St
Houston, Texas 77030
(832) 824-1000
Principal Investigator: Vinitha R Shenava
Texas Children's Hospital Texas Children's Hospital, located in Houston, Texas, is a not-for-profit organization whose...
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Houston, TX
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Loma Linda University
Loma Linda, California 92354
(909) 558-4000
Principal Investigator: Martin Morrison III
Loma Linda University Loma Linda University (LLU) is a Seventh-day Adventist educational health-sciences institution with...
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Loma Linda, CA
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535 E 70th St
New York, New York 10021
(212) 606-1000
Principal Investigator: Emily Dodwell
Hospital for Special Surgery Founded in 1863, Hospital for Special Surgery is the nation
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from
New York, NY
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Wilmington, Delaware 19803
Principal Investigator: Mihir Thacker
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from
Wilmington, DE
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