A Study of Atezolizumab in Combination With Carboplatin + Paclitaxel or Carboplatin + Nab-Paclitaxel Compared With Carboplatin + Nab-Paclitaxel in Participants With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC) [IMpower131]



Status:Active, not recruiting
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/7/2019
Start Date:June 11, 2015
End Date:February 15, 2023

Use our guide to learn which trials are right for you!

A Phase III, Open-Label, Multicenter, Randomized Study Evaluating the Efficacy and Safety of Atezolizumab (MPDL3280A, Anti-PD-L1 Antibody) in Combination With Carboplatin+Paclitaxel or Atezolizumab in Combination With Carboplatin+Nab-Paclitaxel Versus Carboplatin+Nab-Paclitaxel in Chemotherapy-Naive Patients With Stage IV Squamous Non-Small Cell Lung Cancer

This randomized, open-label study will evaluate the safety and efficacy of atezolizumab
(MPDL3280A) in combination with carboplatin + paclitaxel or carboplatin + nab-paclitaxel
compared with treatment with carboplatin + nab-paclitaxel in chemotherapy-naive participants
with Stage IV squamous NSCLC.


Inclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

- Histologically or cytologically confirmed, treatment-naïve Stage IV squamous NSCLC

- Previously obtained archival tumor tissue or tissue obtained from biopsy at screening

- Measurable disease as defined by RECIST v1.1

- Adequate hematologic and end organ function

Exclusion Criteria:

- Active or untreated central nervous system (CNS) metastasis

- Malignancies other than NSCLC within 5 years prior to randomization, with the
exception of those with a negligible risk of metastasis or death treated with expected
curative outcome

- Pregnant or lactating women

- History of autoimmune disease

- History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced
pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening
chest Computed Tomography (CT) scan, History of radiation pneumonitis in the radiation
field (fibrosis) is permitted

- Positive test for Human Immunodeficiency Virus (HIV)

- Active hepatitis B or hepatitis C

- Prior treatment with cluster of differentiation 137 (CD137) agonists or immune
checkpoint blockade therapies, anti-programmed death-1 (anti-PD-1), and anti-PD-L1
therapeutic antibody

- Severe infection within 4 weeks prior to randomization

- Significant history of cardiovascular disease
We found this trial at
85
sites
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
148
mi
from 98109
Portland, OR
Click here to add this to my saved trials
5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
1737
mi
from 98109
Chicago, IL
Click here to add this to my saved trials
4725 North Federal Highway
Fort Lauderdale, Florida 33308
(954) 771-8000
Holy Cross Hospital While spirituality plays an essential role in the way that we minister...
2717
mi
from 98109
Fort Lauderdale, FL
Click here to add this to my saved trials
11143 Parkview Plaza Dr # 100
Fort Wayne, Indiana 46845
(260) 484-8830
Fort Wayne Medical Oncology and Hematology Fort Wayne Medical Oncology and Hematology provides state-of-the-art cancer...
1871
mi
from 98109
Fort Wayne, IN
Click here to add this to my saved trials
2500 Campus Rd
Honolulu, Hawaii 96822
(808) 956-8111
Univ of Hawaii Honolulu Community College is an integral part of the University of Hawai?i,...
2678
mi
from 98109
Honolulu, HI
Click here to add this to my saved trials
Miami, Florida 33136
2730
mi
from 98109
Miami, FL
Click here to add this to my saved trials
1871 SE Tiffany Ave # 100
Port Saint Lucie, Florida 34952
2654
mi
from 98109
Port Saint Lucie, FL
Click here to add this to my saved trials
Ann Arbor, Michigan 48106
1901
mi
from 98109
Ann Arbor, MI
Click here to add this to my saved trials
3320 Old Jefferson Road
Athens, Georgia 30607
2213
mi
from 98109
Athens, GA
Click here to add this to my saved trials
Bend, Oregon 97701
249
mi
from 98109
Bend, OR
Click here to add this to my saved trials
2500 Northeast Neff Road
Bend, Oregon 97701
251
mi
from 98109
Bend, OR
Click here to add this to my saved trials
8901 Rockville Pike
Bethesda, Maryland 20889
(301) 295-4000
Walter Reed National Military Medical Center The Walter Reed National Military Medical Center is one...
2316
mi
from 98109
Bethesda, MD
Click here to add this to my saved trials
701 Ostrum Street
Bethlehem, Pennsylvania 18015
2341
mi
from 98109
Bethlehem, PA
Click here to add this to my saved trials
1351 Kimberly Rd
Bettendorf, Iowa 52722
(563) 355-7733
Hematology Oncology Associates of the Quad Cities
1609
mi
from 98109
Bettendorf, IA
Click here to add this to my saved trials
801 North 29th Street
Billings, Montana 59107
406-238-2500
Billings Clinic Based in Billings, Montana, Billings Clinic is a community-governed health care organization consisting...
668
mi
from 98109
Billings, MT
Click here to add this to my saved trials
1180 Avenida Crámer
Buenos Aires, C1426
6914
mi
from 98109
Buenos Aires,
Click here to add this to my saved trials
Carrollton, Georgia 30117
2154
mi
from 98109
Carrollton, GA
Click here to add this to my saved trials
Chandler, Arizona 85224
1128
mi
from 98109
Chandler, AZ
Click here to add this to my saved trials
Chattanooga, Tennessee 37404
2083
mi
from 98109
Chattanooga, TN
Click here to add this to my saved trials
Cherry Hill, New Jersey
2380
mi
from 98109
Cherry Hill, NJ
Click here to add this to my saved trials
2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
1967
mi
from 98109
Cincinnati, OH
Click here to add this to my saved trials
3100 Plaza Properties Blvd
Columbus, Ohio 43219
(614) 383-6000
The Mark H. Zangmeister Center At The Zangmeister Center, we appreciate that our patients have...
2010
mi
from 98109
Columbus, OH
Click here to add this to my saved trials
Danbury, Connecticut 06810
2405
mi
from 98109
Danbury, CT
Click here to add this to my saved trials
800 West Magnolia Avenue
Denton, Texas 76210
1661
mi
from 98109
Denton, TX
Click here to add this to my saved trials
Denver, Colorado 80218
1021
mi
from 98109
Denver, CO
Click here to add this to my saved trials
Detroit, Michigan 48201
1932
mi
from 98109
Detroit, MI
Click here to add this to my saved trials
1001 East Superior Street
Duluth, Minnesota 55805
1412
mi
from 98109
Duluth, MN
Click here to add this to my saved trials
1717 13th St
Everett, Washington 98201
(425) 297-5500
Providence Regional Cancer Partnership Founded in 2007, the Providence Regional Cancer Partnership is the result...
25
mi
from 98109
Everett, WA
Click here to add this to my saved trials
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
2313
mi
from 98109
Fairfax, VA
Click here to add this to my saved trials
206 Mill Road
Fairhaven, Massachusetts 02719
2515
mi
from 98109
Fairhaven, MA
Click here to add this to my saved trials
4371 Veronica S Shoemaker Boulevard
Fort Myers, Florida 33916
2619
mi
from 98109
Fort Myers, FL
Click here to add this to my saved trials
8116 Good Luck Road
Gettysburg, Pennsylvania 17325
2327
mi
from 98109
Gettysburg, PA
Click here to add this to my saved trials
2055 Hospital Drive
Hamilton, Ohio 45103
1985
mi
from 98109
Hamilton, OH
Click here to add this to my saved trials
Harrisburg, Pennsylvania 17043
2283
mi
from 98109
Harrisburg, PA
Click here to add this to my saved trials
Hazard, Kentucky
2094
mi
from 98109
Hazard, KY
Click here to add this to my saved trials
1720
mi
from 98109
Joliet, IL
Click here to add this to my saved trials
Kansas City, Missouri 64111
1503
mi
from 98109
Kansas City, MO
Click here to add this to my saved trials
Knoxville, Tennessee 37920
2113
mi
from 98109
Knoxville, TN
Click here to add this to my saved trials
Lake Success, New York 11042
2414
mi
from 98109
Lake Success, NY
Click here to add this to my saved trials
450 Lakeville Rd
Lake Success, New York 11040
(516) 734-8900
Monter Cancer Center The Monter Cancer Center is a unique facility dedicated to providing state-of-the-art...
2414
mi
from 98109
Lake Success, NY
Click here to add this to my saved trials
555 N Duke St
Lancaster, Pennsylvania 17602
(717) 544-5511
Lancaster General Hospital For more than a century, Lancaster General Hospital has been a leader...
2315
mi
from 98109
Lancaster, PA
Click here to add this to my saved trials
Lawrenceville, Georgia 30046
2186
mi
from 98109
Lawrenceville, GA
Click here to add this to my saved trials
16 Hayden Avenue
Lexington, Kentucky 02421
2475
mi
from 98109
Lexington, KY
Click here to add this to my saved trials
4301 West Markham Street
Little Rock, Arkansas 72205
1780
mi
from 98109
Little Rock, AR
Click here to add this to my saved trials
Longview, Texas 75601
1779
mi
from 98109
Longview, TX
Click here to add this to my saved trials
Louisville, Kentucky 40207
1944
mi
from 98109
Louisville, KY
Click here to add this to my saved trials
Macon, Georgia 31201
2252
mi
from 98109
Macon, GA
Click here to add this to my saved trials
2160 South 1st Avenue
Maywood, Illinois 60153
(888) 584-7888
Loyola University Medical Center Loyola University Health System is committed to excellence in patient care...
1724
mi
from 98109
Maywood, IL
Click here to add this to my saved trials
1 Medical Center Drive
Morgantown, West Virginia 26506
2160
mi
from 98109
Morgantown, WV
Click here to add this to my saved trials
New Orleans, Louisiana 70121
2095
mi
from 98109
New Orleans, LA
Click here to add this to my saved trials
Newnan, Georgia 30265
2177
mi
from 98109
Newnan, GA
Click here to add this to my saved trials
5900 Lake Wright Dr
Norfolk, Virginia 23502
(757) 466-8683
Virginia Oncology Associates Virginia Oncology Associates is an oncology and hematology practice of physicians, specializing...
2434
mi
from 98109
Norfolk, VA
Click here to add this to my saved trials
Oakland, California 94611
677
mi
from 98109
Oakland, CA
Click here to add this to my saved trials
3401 PGA Boulevard
Palm Beach Gardens, Florida 33410
2684
mi
from 98109
Palm Beach Gardens, FL
Click here to add this to my saved trials
1 Valley Health Plaza
Paramus, New Jersey 07652
2390
mi
from 98109
Paramus, NJ
Click here to add this to my saved trials
Park Ridge, Illinois 60068
1719
mi
from 98109
Park Ridge, IL
Click here to add this to my saved trials
Pittsburgh, Pennsylvania 15212
2131
mi
from 98109
Pittsburgh, PA
Click here to add this to my saved trials
200 Lothrop St
Pittsburgh, Pennsylvania 15213
University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
2134
mi
from 98109
Pittsburgh, PA
Click here to add this to my saved trials
Quincy, Illinois 62301
1621
mi
from 98109
Quincy, IL
Click here to add this to my saved trials
578
mi
from 98109
Reno, NV
Click here to add this to my saved trials
Richmond, Virginia 23235
2346
mi
from 98109
Richmond, VA
Click here to add this to my saved trials
Roanoke, Virginia 24014
2248
mi
from 98109
Roanoke, VA
Click here to add this to my saved trials
Rogers, Arkansas 72758
1632
mi
from 98109
Rogers, AR
Click here to add this to my saved trials
Roseville, California 95661
617
mi
from 98109
Roseville, CA
Click here to add this to my saved trials
2025 Morse Avenue
Sacramento, California 95825
625
mi
from 98109
Sacramento, CA
Click here to add this to my saved trials
1201 5th Avenue North
Saint Petersburg, Florida 33705
2526
mi
from 98109
Saint Petersburg, FL
Click here to add this to my saved trials
Salisbury, North Carolina 28144
?
mi
from 98109
Salisbury, NC
Click here to add this to my saved trials
1783
mi
from 98109
San Antonio, TX
Click here to add this to my saved trials
4647 Zion Avenue
San Diego, California 92120
1061
mi
from 98109
San Diego, CA
Click here to add this to my saved trials
San Francisco, California 94115
680
mi
from 98109
San Francisco, CA
Click here to add this to my saved trials
San Jose, California 95119
719
mi
from 98109
San Jose, CA
Click here to add this to my saved trials
2500 Merced Street
San Leandro, California 94577
685
mi
from 98109
San Leandro, CA
Click here to add this to my saved trials
Santa Clara, California 95051
710
mi
from 98109
Santa Clara, CA
Click here to add this to my saved trials
Scarborough, Maine 04074
2478
mi
from 98109
Scarborough, ME
Click here to add this to my saved trials
9055 East Del Camino Drive
Scottsdale, Arizona 85258
1114
mi
from 98109
Scottsdale, AZ
Click here to add this to my saved trials
Sewell, New Jersey 08080
2386
mi
from 98109
Sewell, NJ
Click here to add this to my saved trials
Sioux City, Iowa 51101
1307
mi
from 98109
Sioux City, IA
Click here to add this to my saved trials
South San Francisco, California 94080
689
mi
from 98109
South San Francisco, CA
Click here to add this to my saved trials
Spokane, Washington 99208
228
mi
from 98109
Spokane, WA
Click here to add this to my saved trials
1705
mi
from 98109
Springfield, IL
Click here to add this to my saved trials
Tallahassee, Florida 32308
2329
mi
from 98109
Tallahassee, FL
Click here to add this to my saved trials
3404 West Sylvania Avenue
Toledo, Ohio 43623
1925
mi
from 98109
Toledo, OH
Click here to add this to my saved trials
1961
mi
from 98109
Tupelo, MS
Click here to add this to my saved trials
Vallejo, California 94589
658
mi
from 98109
Vallejo, CA
Click here to add this to my saved trials
Walnut Creek, California 94596
672
mi
from 98109
Walnut Creek, CA
Click here to add this to my saved trials