A Study of Ixekizumab (LY2439821) in Participants With Active Psoriatic Arthritis



Status:Active, not recruiting
Conditions:Arthritis, Psoriasis
Therapuetic Areas:Dermatology / Plastic Surgery, Rheumatology
Healthy:No
Age Range:18 - Any
Updated:12/16/2017
Start Date:December 2014
End Date:June 2019

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A Multicenter, Randomized, Double-Blind, Placebo Controlled 24-Week Study Followed by Long Term Evaluation of Efficacy and Safety of Ixekizumab (LY2439821) in Biologic Disease-Modifying Antirheumatic Drug-Experienced Patients With Active Psoriatic Arthritis

The main purpose of this study is to evaluate how effective and safe the study drug known as
ixekizumab is in participants with active psoriatic arthritis.


Inclusion Criteria:

- Presents with established diagnosis of active psoriatic arthritis (PsA) for at least 6
months, and currently meets Classification for Psoriatic Arthritis (CASPAR) criteria

- Active PsA defined as the presence of at least 3 tender and at least 3 swollen joints

- Presence of active psoriatic skin lesion or a history of plaque psoriasis (Ps)

- Men must agree to use a reliable method of birth control or remain abstinent during
the study

- Women must agree to use reliable birth control or remain abstinent during the study
and for at least 12 weeks after stopping treatment

- Have been treated with 1 or more conventional disease-modifying antirheumatic drugs
(cDMARDs)

Exclusion Criteria:

- Current use of biologic agents for treatment of Ps or PsA

- Inadequate response to greater than 2 biologic DMARDs

- Current use of more than one cDMARDs

- Diagnosis of active inflammatory arthritic syndromes or spondyloarthropathies other
than PsA

- Have received treatment with interleukin (IL) -17 or IL12/23 targeted monoclonal
antibody (MAb) therapy

- Serious disorder or illness other than psoriatic arthritis

- Serious infection within the last 3 months

- Breastfeeding or nursing (lactating) women
We found this trial at
62
sites
Austin, Texas 78731
1766
mi
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Austin, TX
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800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
2485
mi
from 98109
Boston, MA
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1044 SW 44th Street
Oklahoma City, Oklahoma 73109
405-616-4888
1525
mi
from 98109
Oklahoma City, OK
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
147
mi
from 98109
Portland, OR
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1709 S Rock Rd
Wichita, Kansas 67207
316-689-6629
1440
mi
from 98109
Wichita, KS
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Albany, New York 12206
2351
mi
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Albany, NY
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Albuquerque, New Mexico 87102
1184
mi
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Albuquerque, NM
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Baltimore, Maryland 21224
2331
mi
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Baltimore, MD
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Birmingham, Alabama 35205
2080
mi
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Birmingham, AL
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Boca Raton, Florida 33486
2707
mi
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Boca Raton, FL
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Brooklyn, New York 11201
2403
mi
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Brooklyn, NY
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7750
mi
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Camperdown,
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Cedar Rapids, Iowa 52401
1542
mi
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Cedar Rapids, IA
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Chapel Hill, North Carolina 27599
(919) 962-2211
Univ of North Carolina Carolina’s vibrant people and programs attest to the University’s long-standing place...
2337
mi
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Chapel Hill, NC
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Charlotte, North Carolina 00000
2281
mi
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Charlotte, NC
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2283
mi
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Charlotte, NC
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2500 Metrohealth Dr
Cleveland, Ohio 44109
(216) 778-7800
MetroHealth Med Ctr The MetroHealth System is one of the largest, most comprehensive health care...
2020
mi
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Cleveland, OH
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Clifton, New Jersey 07012
2389
mi
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Clifton, NJ
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Cumberland, Maryland 21502
2215
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Cumberland, MD
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Cypress, Texas 77429
1731
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Cypress, TX
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1681
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Dallas, TX
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Dayton, Ohio 45417
1957
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Dayton, OH
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Duncansville, Pennsylvania 16635
2206
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Duncansville, PA
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Franklin, Wisconsin 53132
1685
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Franklin, WI
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1104
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Glendale, AZ
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Hagerstown, Maryland 21740
2265
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Hagerstown, MD
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Hickory, North Carolina 28602
2238
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Hickory, NC
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1890
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Houston, TX
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1884
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Houston, TX
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Indianapolis, Indiana 46227
1868
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Indianapolis, IN
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Kalispell, Montana 59901
373
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Kalispell, MT
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Kennewick, Washington 99336
181
mi
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Kennewick, WA
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9500 Gilman Dr
La Jolla, California 92093
(858) 534-2230
The University of California, San Diego UC San Diego is an academic powerhouse and economic...
1056
mi
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La Jolla, CA
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LA Mesa, California 91942
1064
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LA Mesa, CA
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Lansing, Michigan 48917
1852
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Lansing, MI
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Lexington, Kentucky 40504
2003
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Lexington, KY
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Limerick, Pennsylvania 19468
2347
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Limerick, PA
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Lincoln, Nebraska 68512
1346
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Lincoln, NE
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Little Rock, Arkansas 72205
1779
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Little Rock, AR
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1440
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Lubbock, TX
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Memphis, Tennessee 38119
1864
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Memphis, TN
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7691 Poplar Avenue
Memphis, Tennessee 38104
1877
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Memphis, TN
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1125
mi
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Mesa, AZ
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Naples, Florida 34102
2643
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Naples, FL
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Nassau Bay, Texas 77058
1912
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Nassau Bay, TX
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2457
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Orange Park, FL
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Palo Alto, California 94305
704
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Palo Alto, CA
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Pensacola, Florida 32514
2195
mi
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Pensacola, FL
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Phoenix, Arizona 85032
1106
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2165
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Rochester, NY
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Saint Louis, Missouri 63110
1718
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Saint Louis, MO
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San Leandro, California 94578
686
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San Leandro, CA
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5300 Tallman Ave NW
Seattle, Washington 98122
(206) 782-2700
Swedish Medical Center Since 1910, Swedish has been the region's hallmark for excellence in health...
2
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Seattle, WA
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Smithtown, New York 11787
2434
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Smithtown, NY
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Spokane, Washington 99204
228
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Spokane, WA
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Toms River, New Jersey 08755
2415
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Toms River, NJ
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Tupelo, Mississippi 38801
1962
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Tupelo, MS
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Tustin, California 92780
987
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Tustin, CA
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2386
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Voorhees, NJ
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Wyomissing, Pennsylvania 19610
2323
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2323
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Wyomissing, PA
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Zephyrhills, Florida 33542
2525
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Zephyrhills, FL
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