An Evaluation Of PF-03715455 In Moderate To Severe Uncontrolled Asthma

Study terminated on 7th April 2015. The termination was due to business reasons. No safety or
efficacy concerns contributed to the termination of the study

Inclusion Criteria:

- Subjects with a physician documented history or diagnosis of persistent asthma
(according to GINA, 2014 definition of asthma),

- Pre bronchodilator FEV1 of greater than or equal to 50 and less that 80% of predicted.

- Subjects defined as GINA Step 4 on a stable dose of either fluticasone/salmeterol
combination therapy, or budesonide/formoterol combination therapy or
mometasone/formoterol combination therapy.

- Subjects who are defined as uncontrolled as evidenced by; Juniper Asthma Control
Questionnaire (5 item version, ACQ) score greater than or equal to 1.5 and less than
or equal to 3.0)

Exclusion Criteria:

- Subjects diagnosed with chronic pulmonary disease (COPD) and/or other chronic
pulmonary diseases (eg, Occupational asthma, pulmonary fibrosis, bronchiectasis,
Allergic bronchopulmonary aspergillosis (ABPA), pneumoconiosis, sarcoidosis,
tuberculosis).

- Subjects who are current smokers.