Prehospital Resuscitation On Helicopter Study

Status:	Completed
Conditions:	Hospital
Therapuetic Areas:	Other
Healthy:	No
Age Range:	15 - Any
Updated:	4/21/2016
Start Date:	January 2015
End Date:	December 2015

The Prehospital Resuscitation On Helicopter Study (PROHS) is a pragmatic, multicenter,
prospective observational study of air ambulance-based prehospital resuscitation regimens
currently utilized at the participating sites. Patients will be enrolled at participating
sites that currently have blood products available on air ambulances and other sites that do
not. This study will not change the current prehospital standard of care for resuscitation.
The primary outcome will be in-hospital mortality and the primary unit of analysis will be
the patient. Other outcomes of interest will include time to hemostasis, hospital
length-of-stay, number of ventilator-free and ICU-free days, incidence of major surgical
procedures, complications (transfusion-related acute lung injury [TRALI], acute kidney
injury [AKI], multiple organ failure [MOF], acute respiratory distress syndrome [ARDS],
sepsis, intra-abdominal complications, thromboembolic complications, compartment syndromes),
lifesaving interventions, the amount and type of blood products and concentrates transfused
(including prehospital), wastage of prehospital blood products and concentrates, use of
external and internal hemostatic devices, and functional status at discharge/discharge
destination.

All patients arriving to the participating center's trauma emergency department via
helicopter directly from the scene will be screened and initial data collected. Of that
group, all patients who meet the "highest risk" category (based on vital signs, type of
injury, use of tourniquet, and/or intubation) or received blood during transport will be
followed through "direct observation" through the initial resuscitation period and then
indirectly through medical chart review until hospital discharge or 30 days after admission
(whichever occurs first).

Inclusion Criteria:

Criteria for "at risk" population

- Patients with traumatic injuries received directly from the scene via air ambulance
service (did not receive a lifesaving intervention at an outside hospital or
healthcare facility)

- Estimated age of 15 or older or greater than/equal to a weight of 50 kg, if age
unknown Criteria for "highest risk" population

- Meet at least one of the following during prehospital care: HR >120 bpm, SBP ≤90
mmHg, penetrating truncal injury, tourniquet application, pelvic binder application
or intubation.

- Received blood products during transport (for those facilities with blood product
availability)

Exclusion Criteria:

- Prisoners (defined as those received directly from a correctional facility.

We found this trial at

sites

University of Arizona

Tucson, Arizona 85721

(520) 621-2211