Quantitative MRI in Assessing Disease in Patients With Brain Tumors

PRIMARY OBJECTIVES:

I. To correlate pre-treatment measures of biophysical parameters in metastases—obtained using
advanced, quantitative MRI techniques in patients receiving standard-of-care (SOC) therapy
for 1-4 brain metastases—with treatment-induced changes in lesion size, time-to-progression
(TTP), and overall survival (OS).

OUTLINE:

Patients undergo hybrid 3 Tesla MRI examination that includes standard MRI sequences,
diffusion-weighted (DW)-MRI, chemical exchange saturation transfer (CEST), and combined
dynamic contrast enhanced (DCE)-MRI/dynamic susceptibility contrast (DSC)-MRI at baseline.

Inclusion Criteria:

- Patients must sign an Institutional Review Board (IRB)-approved informed consent
document

- Patients must have been diagnosed with one of the following:

- Primary brain tumor (glioma, GBM etc); or

- Up to 10 brain metastases

- Patients must have been diagnosed with 1-4 brain metastases

- At least one of the brain metastases must measure 5 mm (or more) in short axis
diameter in the axial plane

- Patients must be scheduled to undergo standard brain cancer interventions:

- Chemotherapy or targeted antiangiogenic therapy, in the case of primary brain
tumor; or

- Stereotaxic radiotherapy (SRS) or whole brain radiotherapy (WBRT), in the case of
brain metastases.

- Patients must be scheduled to receive a 3-Tesla (3T) MRI exam as part of their
standard of care (this exam will be modified to also include pulse sequences with are
for research only)

Exclusion Criteria:

- Patients who have received previous treatment (chemotherapy or radiotherapy) for any
brain tumor (primary or metastatic).

- Patients who are scheduled to receive a 1.5T MRI exam

- Patients incapable of giving informed written consent, due to mental disability,
altered mental status, confusion, cognitive impairment, or psychiatric disorders.

- Patients scoring 14.5 or lower on the University of California, San Diego Brief
Assessment of Capacity to Consent (UBACC) questionnaire will not be allowed on the
study