PK Intravenous Lidocaine Infusion

This study will address the working hypothesis that intravenous lidocaine may be administered
as a bolus followed by an infusion with reliable and safe blood levels of lidocaine. Serial
blood draws will be obtained to determine safety of lidocaine doses used in this study by
measuring blood levels of lidocaine and its metabolites.

Inclusion Criteria:

- male or female children 3-15 years of age

- ASA physical status 1-3

- scheduled for colorectal surgery with abdominal incision

Exclusion Criteria:

- ASA physical status > 3

- postoperative intubation planned ahead of surgery

- history of chronic use of opioid (use longer than 3 months)

- history of hepatic, renal, or cardiac failure

- history of significant liver disease including liver failure, acute or chronic
hepatitis, hepatomegaly, portal hypertension and elevated liver enzymes

- history of organ transplant

- BMI > 30

- history of cardiac arrhythmia

- history of long QT syndrome

- history of allergic reaction to lidocaine or similar agents

- history of seizure disorder

- patient without PICC or other central access with contraindication to inhalation
induction

- family history or known patient susceptibility to malignant hyperthermia