Fludeoxyglucose F 18 Positron Emission Tomography and Magnetic Resonance Perfusion Imaging in Patients With Neurofibromatosis 1 and Plexiform Neurofibroma



Status:Recruiting
Conditions:Cancer, Cancer, Other Indications
Therapuetic Areas:Oncology, Other
Healthy:No
Age Range:Any - 25
Updated:1/1/2014
Start Date:April 2002

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Novel Imaging Modalities For Plexiform Neurofibromas

RATIONALE: New imaging procedures such as fludeoxyglucose F 18 positron emission tomography
(FDG-PET) and magnetic resonance (MR) perfusion imaging may improve the ability to detect
disease progression, help doctors predict a patient's response to treatment, and help plan
the most effective treatment.

PURPOSE: This diagnostic trial is studying how well FDG-PET and MR perfusion imaging work in
finding disease progression and determining response to treatment in patients with
neurofibromatosis 1 and plexiform neurofibroma.

OBJECTIVES:

- Determine whether fludeoxyglucose F 18 positron emission tomography (FDG-PET) and MR
perfusion studies can predict plexiform neurofibroma growth rates in patients with
neurofibromatosis 1.

- Determine whether FDG-PET and MR perfusion studies can predict the likelihood of
response in patients who are undergoing investigational treatment for plexiform
neurofibromas.

- Identify neuroimaging characteristics that distinguish patients who have responded to
therapy from those who have not after completion of treatment.

OUTLINE:

- Stratum 1: Patients undergo MR perfusion scan with gadopentetate dimeglumine and
fludeoxyglucose F 18 positron emission tomography (FDG-PET) at baseline and
quantitative MRI evaluation at baseline and 1 year.

- Stratum 2: Patients undergo quantitative MRI, MR perfusion scan with gadopentetate
dimeglumine, and FDG-PET at baseline and 1 year.

PROJECTED ACCRUAL: A total of 48 patients (32 for stratum 1 and 16 for stratum 2) will be
accrued for this study.

DISEASE CHARACTERISTICS:

- Stratum 1:

- Diagnosis of neurofibromatosis 1 (NF1) and plexiform neurofibromas

- At high risk for progression, as defined by any of the following:

- Anatomic location such that progression carries a high risk of impairment
of function, pain, or disfigurement (e.g., neck/mediastinum, paraspinal
nerve roots, orbit, and face)

- Tumors that the patient, family, or caregiver believes have increased in
size within the past year, but appear stable by standard clinical or
radiographic measures

- No plexiform neurofibromas that are small, cause no pain or functional
impairment, or are not likely to cause pain or functional impairment over the
succeeding 12 months

- Stratum 2:

- Diagnosis of NF1 and progressive plexiform neurofibromas

- Neurofibroma progression documented by increase in lesion size on MRI

- Currently being enrolled on a clinical therapeutic trial at Children's Hospital
of Philadelphia

PATIENT CHARACTERISTICS:

Age

- 25 and under

Performance status

- Not specified

Life expectancy

- Not specified

Hematopoietic

- Not specified

Hepatic

- Not specified

Renal

- Not specified

Other

- Not pregnant or nursing

- Negative pregnancy test

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- Stratum 1:

- No prior or concurrent chemotherapy

- No concurrent enrollment on a chemotherapy clinical trial

- Stratum 2:

- At least 4 weeks since prior chemotherapy

Endocrine therapy

- Not specified

Radiotherapy

- At least 6 weeks since prior radiotherapy (stratum 2)

Surgery

- Prior surgery for progressive plexiform neurofibroma allowed if incompletely resected
and measurable disease remains (stratum 2)
We found this trial at
2
sites
South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
(215) 662-6065
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
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