Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/18/2018 |
| Start Date: | January 2016 |
| End Date: | June 2019 |
| Contact: | Laurie Meade, RN |
| Email: | meade.laurie@mayo.edu |
| Phone: | 507-255-1829 |
This study is designed to determine if point-of-care washing of allogeneic Leukocyte-Reduced
Red Blood Cells reduces pulmonary complications when compared to standard-of-care
Leukocyte-Reduced Red Blood Cells in a cardiac surgical population.
Red Blood Cells reduces pulmonary complications when compared to standard-of-care
Leukocyte-Reduced Red Blood Cells in a cardiac surgical population.
Inclusion Criteria:
- Age equal to or greater than 18 years of age.
- Scheduled to have cardiac bypass surgery at Mayo Clinic in Rochester, Minnesota or
Duke University Medical Center in Durham, North Carolina
- At risk for needing at least 4 units of blood during/after surgery
Exclusion Criteria:
- Emergency surgery
- Immunoglobulin A (IgA) deficiency
- History of severe recurrent transfusion reactions
- Refusal to receive allogeneic blood products
- Refusal to provide informed consent
- Prevalent lung injury prior to randomization
- Prevalent congestive heart failure prior to randomization
- Expected hospital stay < 48 hours
- Not anticipated to survive > 48 hours
- Previously enrolled in this trial
- No plan for placement of a pulmonary artery catheter
- Use of home oxygen therapy
- Complex RBC antibody profiles
- Need for the use of irradiated RBCs
We found this trial at
2
sites
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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200 First Street SW
Rochester, Minnesota 55905
Rochester, Minnesota 55905
507-284-2511
Phone: 507-255-1829
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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