Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:11/18/2018
Start Date:January 2016
End Date:June 2019
Contact:Laurie Meade, RN
Email:meade.laurie@mayo.edu
Phone:507-255-1829

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This study is designed to determine if point-of-care washing of allogeneic Leukocyte-Reduced
Red Blood Cells reduces pulmonary complications when compared to standard-of-care
Leukocyte-Reduced Red Blood Cells in a cardiac surgical population.


Inclusion Criteria:

- Age equal to or greater than 18 years of age.

- Scheduled to have cardiac bypass surgery at Mayo Clinic in Rochester, Minnesota or
Duke University Medical Center in Durham, North Carolina

- At risk for needing at least 4 units of blood during/after surgery

Exclusion Criteria:

- Emergency surgery

- Immunoglobulin A (IgA) deficiency

- History of severe recurrent transfusion reactions

- Refusal to receive allogeneic blood products

- Refusal to provide informed consent

- Prevalent lung injury prior to randomization

- Prevalent congestive heart failure prior to randomization

- Expected hospital stay < 48 hours

- Not anticipated to survive > 48 hours

- Previously enrolled in this trial

- No plan for placement of a pulmonary artery catheter

- Use of home oxygen therapy

- Complex RBC antibody profiles

- Need for the use of irradiated RBCs
We found this trial at
2
sites
200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Phone: 507-255-1829
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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