NOVOCART®3D for Treatment of Articular Cartilage of the Knee



Status:Recruiting
Healthy:No
Age Range:18 - 65
Updated:2/2/2019
Start Date:January 2014
End Date:December 2021
Contact:Jennifer Sisler, BSN, RN
Email:jennifer.sisler@aesculapbiologics.com
Phone:610-984-9066

Use our guide to learn which trials are right for you!

A Phase 3, Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART 3D Compared ot Microfracture in the Treatment of Articular Cartilage Defects

This study is to compare NOVOCART 3D relative to Microfracture for the treatment of knee
cartilage defects. Efficacy will be evaluated by both pain and function. Safety will also be
evaluated.

Subjects with articular knee defects will be randomized to receive either Microfracture or
NOVOCART 3D. Subjects will be followed for five years in total and will be evaluated for
safety and efficacy.

Inclusion Criteria:

- Greater than 18 years old

- Isolated articular cartilage lesions on the femoral condyle 2-6 cm2

- Minimum score on the KOOS questionnaire

Exclusion Criteria:

- Instability of the knee joint

- Arthritis

- Autoimmune disease

- Immune suppression

- Prior surgical treatment using mosaicplasty, autologous chondrocyte implantation
and/or microfracture (debridement and lavage are acceptable beyond three months from
baseline)

- Bone disease

- Any degenerative muscular, connective tissue or neurological condition or other
disease process that would interfere with healing or the evaluation of outcome
measures.
We found this trial at
39
sites
Jackson, Tennessee 38305
Principal Investigator: Jason Hutchison, MD
Phone: 731-431-5027
?
mi
from
Jackson, TN
Click here to add this to my saved trials
13020 N Telecom Pkwy
Tampa, Florida 33637
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Albuquerque, New Mexico 87131
(505) 277-0111
Principal Investigator: Dustin Richter, MD
Phone: 505-272-1223
University of New Mexico Founded in 1889 as New Mexico’s flagship institution, the University of...
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Allentown, Pennsylvania 18104
Principal Investigator: Robert Palumbo, MD
Phone: 610-973-6227
?
mi
from
Allentown, PA
Click here to add this to my saved trials
Altoona, Pennsylvania 16602
Principal Investigator: William Tyndall
Phone: 814-949-4050
?
mi
from
Altoona, PA
Click here to add this to my saved trials
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: John Grant, MD
Phone: 734-930-7432
University of Michigan The University of Michigan was founded in 1817 as one of the...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Bethlehem, Pennsylvania
Principal Investigator: Gregory F Carolan, MD
Phone: 484-526-7825
?
mi
from
Bethlehem, PA
Click here to add this to my saved trials
Boca Raton, Florida 33433
Principal Investigator: Johnathan Hersch, MD
Phone: 561-513-3699
?
mi
from
Boca Raton, FL
Click here to add this to my saved trials
Boise, Idaho 83702
Principal Investigator: James Beckmann, MD
Phone: 208-706-9084
?
mi
from
Boise, ID
Click here to add this to my saved trials
Brunswick, Georgia 31525
?
mi
from
Brunswick, GA
Click here to add this to my saved trials
Charlottesville, Virginia 22903
(434) 924-0311
Principal Investigator: David Diduch, MD
Phone: 434-924-6184
University of Virginia The University of Virginia is distinctive among institutions of higher education. Founded...
?
mi
from
Charlottesville, VA
Click here to add this to my saved trials
1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Principal Investigator: Brian Cole, MD
Phone: 312-563-2216
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Columbus, Ohio 43221
Principal Investigator: David Flanigan, MD
Phone: 614-293-3600
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Denver, Colorado 80220
Principal Investigator: Lorenzo Silvestri, MD
Phone: 303-399-8020
?
mi
from
Denver, CO
Click here to add this to my saved trials
Denver, Colorado 80222
Principal Investigator: Armando Vidal, MD
Phone: 720-848-8200
?
mi
from
Denver, CO
Click here to add this to my saved trials
Edmonton, Alberta T6G 2J2
Principal Investigator: Mark Sommerfeldt, MD
Phone: 780-492-8626
?
mi
from
Edmonton,
Click here to add this to my saved trials
Encinitas, California 92024
Principal Investigator: Gregory Loren, MD
Phone: 760-943-6710
?
mi
from
Encinitas, CA
Click here to add this to my saved trials
Evanston, Illinois 60201
Principal Investigator: Jason Koh, MD
Phone: 847-570-1727
?
mi
from
Evanston, IL
Click here to add this to my saved trials
Hershey, Pennsylvania 17033
Principal Investigator: Robert Gallo, MD
Phone: 717-531-0003
?
mi
from
Hershey, PA
Click here to add this to my saved trials
Houston, Texas 77093
Principal Investigator: Robert Burke, MD
Phone: 713-777-5343
?
mi
from
Houston, TX
Click here to add this to my saved trials
La Mesa, California 91942
Principal Investigator: Scott Hacker, MD
Phone: 619-456-6012
?
mi
from
La Mesa, CA
Click here to add this to my saved trials
Lexington, Kentucky
859) 257-9000
Principal Investigator: Christian Lattermann
Phone: 859-323-2737
University of Kentucky The University of Kentucky is a public, land grant university dedicated to...
?
mi
from
Lexington, KY
Click here to add this to my saved trials
Los Angeles, California 90095
(310) 825-4321
Principal Investigator: Kristofer Jones, MD
UCLA UCLA's primary purpose as a public research university is the creation, dissemination, preservation and...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Lynchburg, Virginia 24501
Principal Investigator: Gautham Gondo, MD
Phone: 434-485-8529
?
mi
from
Lynchburg, VA
Click here to add this to my saved trials
Meridian, Idaho 83642
Principal Investigator: Andrew Curran, CO
Phone: 208-866-5522
?
mi
from
Meridian, ID
Click here to add this to my saved trials
New Orleans, Louisiana 70121
Principal Investigator: Deryk Jones, MD
Phone: 504-842-0263
?
mi
from
New Orleans, LA
Click here to add this to my saved trials
5 East 98th Street
New York, New York 10029
Principal Investigator: James Gladstone, MD
Phone: 212-241-1678
?
mi
from
New York, NY
Click here to add this to my saved trials
Newtown Square, Pennsylvania 19073
?
mi
from
Newtown Square, PA
Click here to add this to my saved trials
North Logan, Utah 84341
Principal Investigator: Brad Larson, MD
Phone: 435-774-8512
?
mi
from
North Logan, UT
Click here to add this to my saved trials
3401 N Broad St
Philadelphia, Pennsylvania
(215) 707-2000
Principal Investigator: J. Milo Sewards, MD
Phone: 215-707-9221
Temple University Hospital On January 18, 1892 a three-story house at 3403 North Broad Street...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Phoenix, Arizona 85023
Principal Investigator: John Brown
Phone: 623-537-5695
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Port Jefferson, New York 11777
Principal Investigator: Michael Fracchia, MD
Phone: 631-747-0008
?
mi
from
Port Jefferson, NY
Click here to add this to my saved trials
Richmond, Virginia 23294
Principal Investigator: Kenneth R Zaslav, MD
Phone: 804-527-6836
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Rochester, Minnesota 55905
Principal Investigator: Aaron Krych, MD
Phone: 507-538-3562
?
mi
from
Rochester, MN
Click here to add this to my saved trials
1 Shields Ave
Sacramento, California 95616
(530) 752-1011
Principal Investigator: Cassandra Lee, MD
Phone: 916-734-8175
University of California-Davis As we begin our second century, UC Davis is poised to become...
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
Springfield, Illinois 62702
?
mi
from
Springfield, IL
Click here to add this to my saved trials
Steamboat Springs, Colorado 80487
Principal Investigator: Alexander Meininger, MD
Phone: 970-879-4612
?
mi
from
Steamboat Springs, CO
Click here to add this to my saved trials
Tulsa, Oklahoma 74146
Principal Investigator: John Balbas, MD
Phone: 918-392-1505
?
mi
from
Tulsa, OK
Click here to add this to my saved trials
Washington, District of Columbia 20037
Principal Investigator: Rajeev Padrinath
Phone: 202-741-2602
?
mi
from
Washington,
Click here to add this to my saved trials