Paclitaxel and Carboplatin With Or Without Sorafenib In The First-Line Treatment Of Patients With Ovarian Cancer



Status:Archived
Conditions:Ovarian Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011

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A Randomized Phase II Study of Paclitaxel/Carboplatin With or Without Sorafenib in the First-Line Treatment of Patients With Stage III/IV Epithelial Ovarian Cancer


This trial will compare the efficacy and toxicity of standard first-line chemotherapy alone
vs. standard chemotherapy + sorafenib in patients with stage III/IV ovarian cancer following
cytoreductive surgery. Patients with residual large volume disease and/or bowel involvement
will be excluded, to minimize the risk of bowel perforation.


All patients must be at least 4 weeks from cytoreductive surgery before starting treatment.
Patients will be randomized to receive treatment with either paclitaxel/carboplatin +
sorafenib or paclitaxel/carboplatin. Paclitaxel/carboplatin will be repeated every 21 days
for a maximum of 6 cycles. Patients with objective response/stable disease after completing
6 courses of chemotherapy will continue sorafenib until disease progression or for a total
of 12 months.

- Regimen A: Paclitaxel 175 mg/m2 1-3 hour IV infusion, Day 1 Carboplatin AUC 6 infused over
20 minutes IV, Day 1 Sorafenib 400mg PO bid

- Regimen B: Paclitaxel 175mg/m2, 1-3 hour IV infusion, Day 1 Carboplatin AUC 6.0, 20 minute
IV infusion, Day 1


We found this trial at
12
sites
Grand Rapids, Michigan 49503
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166 Stoneridge Drive
Columbia, South Carolina 29210
803-461-3000
South Carolina Oncology Associates, PA South Carolina Oncology Associates (SCOA) is the only comprehensive cancer...
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Columbia, SC
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3840 Broadway
Fort Myers, Florida 33901
(239) 275-6400
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Fort Myers, FL
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1099 5th Avenue North
St. Petersburg, Florida 33705
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St. Petersburg, FL
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1120 15th Street
Augusta, Georgia 30912
(706) 721-0211
Med College of Georgia Georgia Regents University, home of the Medical College of Georgia, is...
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Augusta, GA
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6410 Rockledge Dr #660
Bethesda, Maryland 20817
(301) 571-0019
Center for Cancer & Blood Disorders Widely recognized for its compassionate, expert care, the Center...
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Bethesda, MD
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5053 Wooster Rd
Cincinnati, Ohio 45226
(513) 751-2273
Oncology Hematology Care Our more than 60 physicians and advanced practice providers throughout neighborhood offices...
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Cincinnati, OH
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Collierville, Tennessee 38017
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Collierville, TN
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Huntsville, Alabama 35805
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Huntsville, AL
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Jonesboro, Arkansas 72401
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Jonesboro, AR
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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Nashville, TN
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Terre Haute, Indiana 47802
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Terre Haute, IN
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