Phenylephrine Versus Ephedrine in Pre-eclampsia
| Status: | Recruiting |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/17/2018 |
| Start Date: | September 2012 |
| End Date: | January 2020 |
| Contact: | Ashraf S Habib, MD |
| Email: | habib001@mc.duke.edu |
| Phone: | 919-668-6266 |
Impact of Vasopressor Administration on Maternal and Neonatal Outcomes in Women With Pre-eclampsia
Phenylephrine administration is associated with reductions in CO and SctO2 compared with
ephedrine when used for blood pressure management in women with pre-eclampsia undergoing
cesarean delivery under spinal anesthesia.
ephedrine when used for blood pressure management in women with pre-eclampsia undergoing
cesarean delivery under spinal anesthesia.
Inclusion Criteria:
- English speaking
- Age ≥18 yrs
- Pre-eclampsia (mild, or severe)
- Non-laboring women
- CD under spinal anesthesia
Exclusion Criteria:
- Height < 5'0"
- Allergy to phenylephrine or ephedrine, or any other standardized medication
- Severe Cardiac disease in pregnancy with marked functional limitations (NYHA Class III
and IV)
- Patients on Monoamine Oxidase Inhibitors or Tricyclic Antidepressants
- History of recent amphetamine or cocaine use.
- Subject enrollment in another study involving a study medication within 30 days of CD
- Any other physical or psychiatric condition which may impair their ability to
cooperate with study data collection
We found this trial at
1
site
2301 Erwin Rd
Durham, North Carolina 27710
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Ashraf S Habib, MD
Phone: 919-668-6266
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