Neurobiological Predictors of Huntington's Disease (PREDICT-HD)



Status:Active, not recruiting
Conditions:Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - Any
Updated:6/18/2016
Start Date:August 2002
End Date:August 2016

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Neurobiological Predictors of Huntington's Disease Trial

The purpose of this trial is to study early brain and behavioral changes in people who have
the gene expansion for Huntington's disease, but are currently healthy and have no symptoms.

Huntington's Disease (HD) is an inherited disease that causes changes in a person's ability
to control movements, thinking, and feelings. The intent of this study is to learn more
about the beginning changes in thinking skills, emotional regulation, and brain structure
and function as a person begins the transition from health to HD.

Preliminary studies indicate that people with HD may have marked decline before an actual
diagnosis. This study will help reveal the earliest indicators of the disease and what
factors influence the age at which a person carrying the gene develops the disease. It is
necessary to get information on the early stages of HD in order to develop drugs that can
slow or postpone the onset of HD. The investigators hope this study will provide essential
information for future trials of experimental drugs for HD.

During this study, participants will undergo several detailed tests, including MRI scans of
the brain, cognitive assessments, physical exams, bio specimen (blood, urine, cerebral
spinal fluid) collection and neurological and psychiatric testing.

Inclusion Criteria:

- men and women at risk for HD, who have been tested for the HD gene mutation, and who
have not been diagnosed with symptoms of HD (CAG ≥36 for CAG-expanded group or CAG
<36 for CAG-norm group).

Exclusion Criteria:

- diagnosis of manifest HD (at least 50% confidence by neurologist that symptoms are
present);

- clinical evidence of unstable medical or psychiatric illness (including substance
abuse);

- history of sever learning disability or mental retardation;

- history of other CNS disease or event (e.g., seizures or head trauma);

- current treatment with antipsychotic medications, including the traditional
neuroleptics such as haloperidol as well as the atypical antipsychotics risperidone,
clozapine, quetiapine, and olanzapine;

- treatment with phenothiazine-derivative antiemetic medications such as
prochlorperazine, metoclopramide, promethazine, and Inapsine on a regular basis
(greater than 3 times per month);

Specific exclusion criteria for the lumbar puncture:

- Current use of anti-coagulants

- Current use of anti-platelets

- Unable to provide consent for him/herself
We found this trial at
15
sites
San Francisco, California 94143
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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425 University Blvd.
Indianapolis, Indiana 46202
(317) 274-4591
Indiana University INDIANA UNIVERSITY is a major multi-campus public research institution, grounded in the liberal...
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Indianapolis, IN
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101 Jessup Hall
Iowa City, Iowa 52242
(319) 335-3500
Principal Investigator: Jane S Paulsen, PhD
Phone: 319-353-4558
University of Iowa With just over 30,000 students, the University of Iowa is one of...
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Los Angeles, California 90095
310-825-4321
University of California at Los Angeles The University of California, Los Angeles (UCLA) is an...
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116th St and Broadway
New York, New York 10027
(212) 854-1754
Columbia University In 1897, the university moved from Forty-ninth Street and Madison Avenue, where it...
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60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
University of Rochester The University of Rochester is one of the country's top-tier research universities....
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Rochester, NY
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Seattle, Washington 98104
(206) 543-2100
Univ of Washington Founded in 1861 by a private gift of 10 acres in what...
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Seattle, WA
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2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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Englewood, Colorado
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1 Shields Ave
Sacramento, California 95616
(530) 752-1011
University of California-Davis As we begin our second century, UC Davis is poised to become...
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St. Louis, Missouri 63108
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Wichita, KS
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