The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconstructive Surgery
| Status: | Recruiting |
|---|---|
| Conditions: | Other Indications |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/17/2018 |
| Start Date: | July 2013 |
| End Date: | September 2019 |
| Contact: | Jeffrey S Moyer, MD |
| Email: | jmoyer@med.umich.edu |
| Phone: | 734-936-8051 |
Antibiotics are sometimes prescribed to patients who have had reconstructive surgery of
wounds on their face using skin grafts. But, it is not yet known whether antibiotics improve
the healing of skin grafts and reduce the risk of infections after surgery in these patients.
It is known that antibiotics, like all medications, have side-effects although these are
rare. This research study is designed to show us whether antibiotics improve wound healing or
not, so that we may determine if we should continue using antibiotics even if they have
side-effects in some patients.
Our hypothesis is that patients treated with post-operative, systemic antibiotics will
demonstrate a statistically significant improvement in the survival of their facial full
thickness skin grafts compared to patients who are not treated with systemic antibiotics.
wounds on their face using skin grafts. But, it is not yet known whether antibiotics improve
the healing of skin grafts and reduce the risk of infections after surgery in these patients.
It is known that antibiotics, like all medications, have side-effects although these are
rare. This research study is designed to show us whether antibiotics improve wound healing or
not, so that we may determine if we should continue using antibiotics even if they have
side-effects in some patients.
Our hypothesis is that patients treated with post-operative, systemic antibiotics will
demonstrate a statistically significant improvement in the survival of their facial full
thickness skin grafts compared to patients who are not treated with systemic antibiotics.
Inclusion Criteria:
- all adult patients with a nasal or facial skin/soft tissue defect requiring
reconstruction limited to or including a full-thickness skin graft
Exclusion Criteria:
- current or recent (within one week of surgery) systemic antibiotic use, intolerance to
both clindamycin and cephalexin, discovery of a persistent cutaneous malignancy at the
site of the defect following the reconstructive procedure and previous reconstruction
at the site of the skin/soft-tissue defect.
We found this trial at
1
site
500 S State St
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Jeffrey Moyer, MD
Phone: 734-936-8051
University of Michigan The University of Michigan was founded in 1817 as one of the...
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