CT in Diagnosing Patients With Lung Cancer

PRIMARY OBJECTIVES:

I. Conduct a prospective clinical imaging study to quantify the amount of inter- and
intra-physician contouring variability on four dimensional (4D) CT, active breathing control
(ABC) CT, free breathing CT, and free breathing and ABC cone beam (CB)CT.

II. Quantify the magnitude and distribution of target and organ at risk volume variations
between the different imaging modalities.

III. Determine dosimetric changes related to contouring variations for tumor and normal
tissue.

OUTLINE:

Patients undergo conventional free breathing CT, 4D CT, ABC CT, ABC CBCT, and free breathing
CBCT before undergoing radiation therapy.

Inclusion Criteria:

- Measurable disease on CT scan

- Patients with lung cancer visible on CT who are scheduled to receive external beam
radiation treatment will be eligible for this study

- Patients must be able to perform ABC procedures

Exclusion Criteria:

- Patients requiring continuous supplemental oxygen due to the requirement of
spirometry during all imaging studies

- No vulnerable populations will be enrolled (prisoners, children, pregnant females or
institutionalized individuals)

- Women of childbearing potential will undergo a pregnancy test