Freezing of Gait in Parkinson's Disease

This study is a randomized, prospective, single-blinded six-week study in PD patients with
freezing of gait (FOG).

This study will involve 2 study groups:

Group A - training group; Group B - no training group/controls.

Both groups will complete a gait evaluation and neuropsychological testing. Group A will
also practice an in-home visuospatial task for 30 minutes, 4-6 days per week for six weeks.
Group B will not complete the in-home tasks.

Participation in this study is expected to last 6-8 weeks.

Inclusion Criteria:

- Age: greater than 18 years old and without an upper age limit

- diagnosis of idiopathic PD exhibiting at least 2 or 3 cardinal signs (bradykinesia,
rigidity, and resting tremor)

- Ambulate independently without an assistive device for at least 60 meters

- Freezing of gait episodes confirmed through the FOG-Q and evaluation by a fellowship
trained Movement Disorder neurologist

- Willingness and ability to participate in training and complete training diary

- Documented FOG-Q and Unified Parkinson's Disease Rating Scale (UPDRS) II

- Ability to sign informed consent

- Pregnant females will be included in the study and there are no known risks to the
pregnant female or fetus

Exclusion Criteria:

- Inability to complete questionnaires

- Unwillingness to participate in training, complete all questionnaires and training
diary

- Subjects with secondary causes of parkinsonism

- Significant dementia (MOCA <20)

- Prior deep brain stimulation (DBS) surgery or pallidotomy

- Subjects cannot participate in any form of Physical Therapy, Occupational Therapy or
Speech Therapy during the study period

- Subjects cannot start any new medications during the study period.