Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial



Status:Archived
Conditions:Peripheral Vascular Disease, Cardiology, Neurology
Therapuetic Areas:Cardiology / Vascular Diseases, Neurology
Healthy:No
Age Range:Any
Updated:7/1/2011

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The purpose of this study is to determine which of two treatments, Warfarin or aspirin, is
better for preventing death and stroke in patients with poor heart function.


Warfarin has proven effective in patients with ischemic heart disease, especially in the
reduction of stroke, death and re-infarction following myocardial infarction, and in the
reduction of stroke in atrial fibrillation. Warfarin is the most promising unstudied
intervention in patients with cardiac failure. This randomized, double-blind, multi-center
study will define optimal antithrombotic therapy for patients with cardiac (heart) failure
and patients with low ejection fraction (EF). EF is the proportion of left ventricular
volume emptied during systole. It reliably measures left ventricular systolic function.

With the rapidly increasing numbers of elderly patients with heart failure, this study has
important public health implications. The study will determine which of two commonly used
treatments Warfarin, an anticoagulant, or aspirin, a drug which affects platelet function is
better for preventing death and stroke in patients with low ejection fraction.


We found this trial at
52
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3400 Spruce St
Philadelphia, Pennsylvania 19104
 (215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
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43 New Scotland Avenue
Albany, New York 12208
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1853 West Polk Street
Chicago, Illinois 60612
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Gainesville, Florida 30501
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1500 Northwest 12th Avenue # 106
Miami, Florida 33136
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Miami, FL
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1 Gustave L Levy Pl # 271
New York, New York 10029
 (212) 241-6500
Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
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7421 N University Dr # 112
Tamarac, Florida
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Allentown, Pennsylvania 18104
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Atlanta, Georgia 30310
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1300 Morris Park Ave
Bronx, New York 10461
(718) 430-2000
Albert Einstein College of Medicine The Albert Einstein College of Medicine of Yeshiva University is...
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Buffalo, New York
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Burlington, Maine 01805
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Burlington, ME
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Cedarhurst, New York
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101 Manning Dr
Chapel Hill, North Carolina 27599
(919) 966-4131
University of North Carolina Hospital at Chapel Hill The UNC Health Care System is a...
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Cleveland, Ohio 44109
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Concord, New Hampshire
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Denver, Colorado 80204
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East Orange, New Jersey 07018
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Fort Meade, South Dakota
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Ft Sam Houston, Texas 78234
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Huntington, West Virginia
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Jacksonville, Florida
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Lexington, Kentucky 40536
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Los Angeles, California 90073
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530 S Jackson St
Louisville, Kentucky 40202
502-562-3226
University of Louisville Hospital As the academic hospital at the heart of the Louisville Metro...
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Louisville, Kentucky 40121
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Madison, WI
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Melbourne, Florida 32901
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Metairie, Louisiana
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Miami, Florida
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Muskegon, Michigan
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New Brunswick, New Jersey 08901
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270-05 76th Ave
New Hyde Park, New York 11040
(718) 470-7480
Long Island Jewish Medical Center Serving North Shore LIJ Health System employees and their families....
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722 W 168th St
New York, New York 10032
(212) 305-2500
Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
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Northport, New York 11768
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Oklahoma City, Oklahoma 73104
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Omaha, Nebraska 68105
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Peoria, Illinois 61606
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Philadelphia, Pennsylvania 19104
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3401 N Broad St
Philadelphia, Pennsylvania
(215) 707-2000
Temple University Hospital On January 18, 1892 a three-story house at 3403 North Broad Street...
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Pittsburgh, Pennsylvania 15212
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Reno, NV
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601 Elmwood Ave
Rochester, New York 14642
(585) 275-2100
Strong Memorial Hospital (University of Rochester School of Medicine) In addition to offering traditional and...
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Salem, Virginia 24153
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Santa Clara, California
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Shreveport, Louisiana 71106
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Tucson, AZ
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Washington, Washington DC 20052
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