Ketogenic Diet for Refractory Status Epilepticus



Status:Recruiting
Conditions:Neurology, Epilepsy
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:18 - 80
Updated:4/21/2016
Start Date:November 2012
Contact:Mackenzie C. Cervenka, M.D.
Email:mcerven1@jhmi.edu
Phone:443-287-0423

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Feasibility and Tolerability of the Ketogenic Diet in the Treatment of Refractory Status Epilepticus in a Neurointensive Care Unit.

This research is being done to observe the safety, tolerability, side effects, and
effectiveness of the ketogenic diet in people with continuous seizures (status epilepticus)
being treated in a neurointensive care unit.


Inclusion Criteria:

- Patients 18 years and older in refractory status epilepticus (continuous or recurrent
seizures without return to baseline mental status between seizures, lasting > 30
minutes) placed on anesthetics/sedating agents (barbiturates or benzodiazepines)
after at least one first- and second-line agent failed to control seizures, and with
clinical and/or electrographic seizures following attempt to wean anesthetic/sedating
agents after 24 hours.

Exclusion Criteria:

1. Unstable metabolic condition

2. Hemodynamic or cardiorespiratory instability

3. Coagulopathy

4. Liver failure

5. Total cholesterol > 300 mg/dL

6. Inability to tolerate enteral feeds, including ileus

7. Pregnancy

8. Family refusal/no consent

9. Received any propofol infusions within 24 hours

10. Known fatty acid oxidation disorder or pyruvate carboxylase deficiency
We found this trial at
9
sites
1301 Punchbowl St
Honolulu, Hawaii 96813
(808) 538-9011
Phone: 808-691-7152
Queen's Medical Center The Queen's Medical Center, located in downtown Honolulu, Hawaii, is a private,...
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Honolulu, HI
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Principal Investigator: Mackenzie C. Cervenka, MD
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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Baltimore, MD
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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Chicago, IL
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5121 S Cottonwood St
Murray, Utah 84157
(801) 507-7000
Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
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Murray, UT
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70 Washington Square S
New York, New York 10012
(212) 998-1212
New York University More than 175 years ago, Albert Gallatin, the distinguished statesman who served...
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New York, NY
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1020 Walnut St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...
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Philadelphia, PA
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5777 East Mayo Boulevard
Phoenix, Arizona 85054
(480) 515-6296
Phone: 480-342-1386
Mayo Clinic Mayo Clinic's campus in Arizona provides medical care for thousands of people from...
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Phoenix, AZ
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Rochester, Minnesota 55905
Principal Investigator: Sara E. Hocker, MD
Phone: 507-774-4741
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Rochester, MN
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