Genetics of Latent Autoimmune Diabetes in Adults

Therapuetic Areas:Endocrinology
Age Range:25 - Any
Start Date:July 2011
End Date:March 2017

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A Study of the Genetic Causes of Latent Autoimmune Diabetes in Adults

This is a prospective study that will study adults and has the objective of examining
'Latent Autoimmune Diabetes in Adults' (LADA) to understand how this trait is influenced by
genetic factors.

A case-control study approach will be used to compare the allelic frequencies of
Deoxyribonucleic acid (DNA) markers of the cases (i.e., LADA patients) to a randomly
selected control samples that does not have the trait under study. To study the role of
genetic factors in LADA, the study seeks to determine if certain genomic regions that are
captured or mirrored by selective Single nucleotide polymorphisms (SNPs) that are genotyped,
are over or underrepresented in those with the disease compared to those who do not. The
level of auto-antibodies is the serum can also be studied as a quantitative trait where we
ask the question if there is correlation with specific SNP alleles that are genotyped. The
markers that are found to be over or under-represented in the study cases will then be
tested in an independent set of patients also recruited in this study. This allows us to
filter markers that show significance simply by chance and prevents us from being misled.

Inclusion Criteria:

- Diagnosed type 2 Diabetes (T2D) patient with: BMI <30 at diagnosis; Age >25-<50 at


- Diagnosed type 1 Diabetes (T1D) patient with: Age >25 at diagnosis


- Currently Diagnosed with LADA with age at initial diagnosis of Diabetes >25 years and a
positive GAD65 antibody test

Exclusion Criteria:

- Any underlying disease or condition that is a contraindication for obtaining 18.0 ml
of blood.

- Inability to obtain an informed consent from a given LADA case.

- Blood sampling has already occurred for a given subject.

- Previous GAD65 antibody test(s) negative.
We found this trial at
South 34th Street
Philadelphia, Pennsylvania 19104
Principal Investigator: Struan Grant, Ph.D.
Phone: 215-590-6815
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
Philadelphia, PA
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Leicester, LE2 2LD
Principal Investigator: Kamlesh Khunti, MD, PhD
Phone: (44) 116 2588850
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