Analyses of Human Samples Collected in Clinical Trials



Status:Enrolling by invitation
Conditions:Prostate Cancer, Cancer, Cancer, Blood Cancer, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:Any - 100
Updated:4/6/2019
Start Date:July 2, 2003

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Pharmacological Analysis of Human Samples Collected in Clinical Trials Performed Outside of the Intramural National Cancer Institute

Cancer patients in clinical trials donate various human samples (e.g., serum, plasma, blood,
urine, feces, bile, saliva) for research purposes.

The purpose of this study is to conduct further analyses on these existing samples from
clinical trials that are being performed outside of, but in collaboration with, the National
Cancer Institute.

Various human samples (e.g., serum, plasma, whole blood, erythrocytes, urine, feces, bile,
and/or saliva) will be collected from cancer patients enrolled on approved clinical trials,
in accordance with the local protocol. These trials are being conducted at outside
institutions, in collaboration with the National Cancer Institute (NCI) and the samples will
be sent to the NCI for pharmacological analysis, involving determination of parent drug
and/or metabolite concentrations and subsequent pharmacokinetics and statistical data
analysis. This study aims to further characterize the clinical pharmacokinetic behavior of
select cancer therapeutics. Future collaborators will be added via the protocol amendment
procedure.

- INCLUSION CRITERIA:

Any patients entered on approved trials of cancer therapeutics or agents that are commonly
administered to patients with cancer at institutions outside of the intramural NCI are
eligible for inclusion, provided that they have consented to pharmacological analysis in
the original consent form.

EXCLUSION CRITERIA:

None anticipated at this time.
We found this trial at
16
sites
10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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Cleveland, OH
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621 West Lombard Street
Baltimore, Maryland 21201
(410) 706-7101
University of Maryland, Baltimore Welcome to the University of Maryland, Baltimore (UMB) founded in 1807...
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Baltimore, MD
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Baltimore, Maryland 21231
Phone: Not Listed
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Baltimore, MD
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86 Jonathan Lucas Street
Charleston, South Carolina 29425
(843) 792-0700
Hollings Cancer Center at Medical University of South Carolina Located at the Medical University of...
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Charleston, SC
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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1201 Broad Rock Boulevard
Richmond, Virginia 23249
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Richmond, VA
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Baltimore, Maryland 21231
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Baltimore, MD
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9000 Rockville Pike
Bethesda, Maryland 20892
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Bethesda, MD
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Lancaster, PA
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Leiden,
Phone: Not Listed
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Leiden,
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3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
(215) 662-6065
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
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Philadelphia, PA
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5150 Centre Avenue
Pittsburgh, Pennsylvania 15261
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Pittsburgh, PA
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Richmond, VA
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200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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Rochester, MN
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Tampa, FL
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111 Michigan Ave NW
Washington, District of Columbia
(202) 476-5000
Childrens National Medical Center As the nation’s children’s hospital, the mission of Children’s National Medical...
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Washington,
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