GLOBAL Clinical Study



Status:Active, not recruiting
Conditions:Peripheral Vascular Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 90
Updated:4/21/2016
Start Date:December 2012
End Date:December 2016

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Genetic Loci and the Burden of Atherosclerotic Lesions

The GLOBAL study is an international multi-center, prospective study designed to enroll up
to 10,000 consecutive eligible subjects who are clinically referred for coronary CT
angiography for assessment of suspected coronary artery disease (CAD).

The purpose of the study is to perform extensive biomarker analysis of atherosclerosis in
patients phenotyped using advanced imaging modalities of atherosclerosis.


Inclusion Criteria:

1. Ages 18-90

2. Caucasian and of Non-Hispanic or Non-Latino origin

3. Referral for coronary CT angiography to evaluate for presence of CAD

4. The patient has signed the appropriate Institutional Review Board approved Informed
Consent Form

Exclusion Criteria:

1. Immunosuppressive or immunomodulatory therapy including any dose of systemic
corticosteroids in the preceding 30 days (except if steroids are administered as
pre-medication prior to contrast administration for CT scan within 24 hours).

2. Chemotherapy in the preceding year

3. Major surgery in the preceding 2 months

4. Blood or blood product transfusion in the preceding 2 months

5. Subjects for whom coronary CT angiography is contraindicated per institutional
standard of care

6. Subjects with previous coronary arterial revascularization (PCI or CABG)

7. Subjects with atrial fibrillation/flutter or frequent irregular or rapid heart
rhythms, which occurred within the past 3 months

8. Subjects with a pacemaker or implantable cardioverter-defibrillator implant

9. Active congestive heart failure or the presence of known non-ischemic cardiomyopathy

10. Known genetic disorders of atherosclerosis, lipid or lipoprotein metabolism
We found this trial at
30
sites
Minneapolis, Minnesota 55407
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Minneapolis, MN
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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Minneapolis, Minnesota 55455
(612) 625-5000
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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Minneapolis, MN
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1120 15th Street
Augusta, Georgia 30912
(706) 721-0211
Georgia Regents University Georgia Regents University, home of the Medical College of Georgia, is one...
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Augusta, GA
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Baton Rouge, Louisiana 70806
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Baton Rouge, LA
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8901 Rockville Pike
Bethesda, Maryland 20889
(301) 295-4000
Walter Reed National Military Medical Center The Walter Reed National Military Medical Center is one...
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Bethesda, MD
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Charlottesville, Virginia 22903
(434) 924-0311
University of Virginia The University of Virginia is distinctive among institutions of higher education. Founded...
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Charlottesville, VA
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Cincinnati, OH
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Cincinnati, OH
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Colorado Springs, Colorado
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Colorado Springs, CO
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Columbus, Ohio 43214
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Columbus, OH
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Darlinghurst, New South Wales 2010
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Darlinghurst,
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Farmington Hills, Michigan 48334
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Farmington Hills, MI
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Huntsville, Alabama 35801
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Huntsville, AL
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Kansas City, MO
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Miami Beach, Florida
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Miami Beach, FL
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Mineloa, New York
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Mineloa, NY
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Pittsburgh, Pennsylvania 15212
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Puyallup, Washington 98372
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Roseville, California 95661
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Roseville, CA
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Roslyn, New York 11576
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Royal Oak, Michigan 48073
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Royal Oak, MI
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St. Paul, Minnesota 55102
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St. Paul, MN
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Stony Brook, New York
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Stony Brook, NY
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Tucson, Arizona 85721
(520) 621-2211
University of Arizona The University of Arizona is a premier, public research university. Established in...
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Washington, District of Columbia
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Washington,
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West Des Moines, Iowa 50266
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West Des Moines, IA
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Wyomissing, Pennsylvania 19610
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Wyomissing, PA
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