Relationship Between Attention and Emotional Regulation Post-Traumatic Brain Injury (TBI)



Status:Recruiting
Conditions:Hospital, Neurology
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:18 - 85
Updated:10/11/2018
Start Date:August 2012
End Date:June 2019
Contact:Preeti Raghavan, MD
Email:preeti.raghavan@nyumc.org
Phone:212-263-0344

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Relationship Between Attention and Emotional Regulation Post-TBI: Probing Neural Circuitry With Transcranial Direct Current Stimulation

The purpose of this pilot study is to investigate the relationship between attention and
emotional function post-Traumatic Brain Injury (TBI) in an effort to better understand the
cognitive mechanisms of emotional processing in patients with TBI, and explore novel
treatment strategies to improve emotional regulation using with transcranial direct current
stimulation (tDCS) to modulate activity in the dysfunctional prefrontal-limbic circuits.

Thirty (30) individuals status post TBI with complaints of emotional dysfunction 6 months
post-brain injury and Fifteen (15) healthy controls will participate in the study. The
experimental group will receive active tDCS for 20 minutes and computerized cognitive
training twice a week for 30-45 minutes for 6 weeks as described below. The control group
will receive sham-tDCS 20 minutes and computerized cognitive training for 30-45 minutes twice
a week for 6 weeks (12 training sessions). The sham group will not receive real tDCS after
completion of the study.

Inclusion Criteria:

- Brain Injury at least 6 months prior

- Family or self-identification of cognitive or emotional difficulties

- Unchanged and stabilized medical treatment in the three weeks prior to the screening

Exclusion Criteria:

- Any social or medical problem that precludes completion of the protocol.

- Presence of focal motor deficits in the upper extremities.

- Comorbid psychiatric disease such as schizophrenia, or active substance abusers
(except nicotine).

- History of craniectomy, active infection, or seizure activity beyond 1 week post-TBI.

- Complicating medical problems such as uncontrolled hypertension, diabetes with signs
of neuropathy, and previous neurological illness such as head trauma, prior stroke,
epilepsy or demyelinating disease, implanted neuromodulatory or electronic device,
metal in head

- Pregnancy
We found this trial at
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550 1st Ave
New York, New York 10016
(212) 263-7300
Principal Investigator: Preeti Raghavan, MD
Phone: 212-263-0344
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