Safety Study of the Selective Inhibitor of Nuclear Export (SINE) KPT-330 in Patients With Advanced Hematological Cancer

Inclusion Criteria

1. Malignancies that are refractory to or intolerant of established therapy known to
provide clinical benefit. Patients must not be candidates for anti-tumor regimes known
to provide clinical benefit.

2. All patients must have evidence of progressive disease on study entry.Previously
untreated patients who are not chemotherapy candidates on Arm 2 may have advanced
disease (without clear progression). There is no upper limit on the number of prior
treatments provided that all inclusion criteria are met and exclusion criteria are not
met.

Exclusion Criteria

1. Radiation, chemotherapy, or immunotherapy or any other anticancer therapy ≤2 weeks
prior to cycle 1 day 1 and mitomycin C and radioimmunotherapy 6 weeks prior to cycle 1
day 1.

2. Patients with active graft versus host disease after allogeneic stem cell
transplantation. At least 3 months must have elapsed since completion of allogeneic
stem cell transplantation except for patients with AML, where at least 2 months must
have elapsed;

3. Known active hepatitis A, B, or C infection; or known to be positive for HCV RNA or
HBsAg (HBV surface antigen);

4. Patients with active CNS malignancy. Asymptomatic small lesions are not considered
active. Treated lesions may be considered inactive if they are stable for at least 3
months. Patient with malignant cells in their cerebrospinal fluid (CSF) without CNS
symptom may be included.

5. Significantly diseased or obstructed gastrointestinal tract or uncontrolled vomiting
or diarrhea.

6. Grade ≥2 peripheral neuropathy at baseline (within 14 days prior to cycle 1 day 1).

7. Macular degeneration, uncontrolled glaucoma, or markedly decreased visual acuity.

8. In the opinion of the investigator, patients who are significantly below their ideal
body weight.