Treatment of Residual Amblyopia With Donepezil



Status:Recruiting
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:8 - Any
Updated:12/21/2018
Start Date:August 2012
End Date:December 2019
Contact:Sarah Whitecross, OC(C)
Email:sarah.whitecross@childrens.harvard.edu
Phone:781-216-1463

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Recovery From Amblyopia With Cholinesterase Inhibitors

Amblyopia is the leading cause of monocular visual impairment in children and adults. Despite
conventional treatment with patching or eye drops, many older children and adults do not
achieve normal vision in the amblyopic eye.

Donepezil is an acetylcholinesterase inhibitor that increases levels of the neurotransmitter
acetylcholine in the brain. Use of acetylcholinesterase inhibitors has been demonstrated by
the Hensch lab (Department of Neurology, FM Kirby Neurobiology Center) at Boston Children's
Hospital to improve vision and reverse amblyopia in animal models.

The purpose of this study is to evaluate the efficacy of oral donepezil as treatment for
residual amblyopia (20/50 - 20/400) in patients 8 years of age and older.


Inclusion Criteria:

1. Age ≥8 years

2. Amblyopia associated with strabismus and/or anisometropia

3. Amblyopic eye visual acuity of 20/50 - 20/400

4. Sound eye visual acuity of ≥20/25

5. For 8 to 17 year olds, current amblyopia treatment of at least 2 hours of daily
patching for at least 4 weeks during the pre-enrollment period with no improvement in
best-corrected amblyopic eye visual acuity (<5 letters or 1 logMAR line between 2
consecutive visual acuity measurements at least 4 weeks apart while on current
treatment)

6. For ≥18 year olds, history of prior amblyopia treatment with patching

7. Wearing optimal optical correction with stable amblyopic eye visual acuity (<5 letters
or 1 logMAR line of improvement during 2 consecutive visual acuity measurements at
least 4 weeks apart)

8. Complete eye examination within 6 months prior to enrollment

9. Available for at least 6 months of follow-up, have access to a phone, and willing to
be contacted by clinical staff

10. Likely to comply with prescribed treatment and unlikely, if applicable, to continue to
improve with 2 hours of daily patching alone

Exclusion Criteria:

1. Myopia more than -6.00 D spherical equivalent

2. Presence of associated findings that could cause reduced visual acuity

3. Previous intraocular or refractive surgery

4. Strabismus surgery planned within 22 weeks

5. Current vision therapy or orthoptics

6. Treatment with topical atropine within the past 4 weeks

7. Presence of cardiac condition, asthma, obstructive pulmonary disease, seizure
disorder, urinary incontinence, and/or peptic ulcer disease receiving concurrent
NSAIDs

8. History of gastrointestinal bleeding from peptic ulcer disease

9. Known psychological problems

10. Known skin reaction to patch or bandage adhesives for 8 to 17 year olds

11. Known allergies or contraindications to the use of acetylcholinesterase inhibitors

12. Prior acetylcholinesterase inhibitor treatment

13. Current use of medication for the treatment of ADHD or psychological disorders

14. Inability to swallow pills equivalent in size to the 5 mg donepezil tablet

15. Females who are pregnant, lactating, or intending to become pregnant within the next 6
months
We found this trial at
3
sites
Waltham, Massachusetts 02453
Principal Investigator: Carolyn Wu, MD
Phone: 781-216-1463
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300 Longwood Ave
Boston, Massachusetts 02115
(617) 355-6000
Principal Investigator: Carolyn Wu, MD
Phone: 781-216-1463
Boston Children's Hospital Boston Children's Hospital is a 395-bed comprehensive center for pediatric health care....
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Weymouth, Massachusetts 02190
Principal Investigator: Carolyn Wu, MD
Phone: 781-216-1463
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Weymouth, MA
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