Coronary Artery Study in Pediatric Heart Transplantation
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 7 - 21 |
| Updated: | 4/2/2016 |
| Start Date: | April 2012 |
| Contact: | Boban P Abraham, MD |
| Email: | bpabraham@uams.edu |
| Phone: | 5013645125 |
Transplant coronary artery disease (TCAD) is a significant cause of morbidity and mortality
in pediatric heart transplantation (PHT). Understanding the pathophysiology and early
detection along with attempted medical management are crucial in preventing advancement of
the disease and retransplantation or mortality. Coronary angiogram, although routinely used
is insensitive to detect early TCAD. Measurement of fractional flow reserve (FFR), coronary
flow reserve (CFR) and index of microvascular resistance (IMR) using a doppler pressure and
flow intracoronary wire may be more sensitive in evaluating the integrity of coronary
vasculature and thus detect pre clinical TCAD. To the best of the investigators knowledge,
measurement of these parameters has not been previously reported in PHT.
in pediatric heart transplantation (PHT). Understanding the pathophysiology and early
detection along with attempted medical management are crucial in preventing advancement of
the disease and retransplantation or mortality. Coronary angiogram, although routinely used
is insensitive to detect early TCAD. Measurement of fractional flow reserve (FFR), coronary
flow reserve (CFR) and index of microvascular resistance (IMR) using a doppler pressure and
flow intracoronary wire may be more sensitive in evaluating the integrity of coronary
vasculature and thus detect pre clinical TCAD. To the best of the investigators knowledge,
measurement of these parameters has not been previously reported in PHT.
Inclusion Criteria:
- less than 21 years and above 7 years of age
Exclusion Criteria:
- clinically significant coronary artery disease on angiography and inability to
undergo IVUS
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Arkansas Children's Hospital Arkansas Children's Hospital (ACH) is the only pediatric medical center in Arkansas...
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