Human Papillomavirus (HPV) Oral Transmission Study in Partners Over Time



Status:Recruiting
Conditions:Cancer, Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases, Oncology
Healthy:No
Age Range:18 - Any
Updated:5/27/2013
Start Date:October 2009
End Date:May 2017

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This research is being done to understand more about a sexually transmitted virus called
Human papillomavirus (HPV) in people with oropharyngeal cancer and their partners.


This study evaluates oral HPV infection and risk factors in people with head and neck cancer
and their partners or spouses. The study focuses on oropharyngeal cancer patients and
includes patients with HPV-associated and HPV-unassociated disease. A comparison group of
people without cancer (controls) are also being enrolled. Couples are followed
longitudinally and there is a repository of study samples. It is hoped that this research
will help us understand risk factors for oral HPV infection, persistence and transmission as
well as researching biomarkers for HPV-associated oral cancer and survival.

The study is led by Dr Amber D'Souza (Johns Hopkins) and laboratory testing for the study is
performed in the laboratory of study co-investigator Dr Maura Gillison (Ohio University).
The study biorepository is led by Dr karen Anderson (Arizona State). Participants are being
enrolled at four sites across the United States including: Mt Sinai (site PI Dr Marshall
Posner), Johns Hopkins (site PI Dr Sara Pai), Dana Farber Cancer Institute (site PI Dr
Robert Haddad) and Oregon Health and Science University (site PI Dr Neil Gross).

Inclusion Criteria:

- 18 years or older and incident oropharyngeal cancer

Exclusion Criteria:

- Presence of medical or psychiatric condition affecting ability to give voluntary,
informed consent

- Cancer patients with a history of organ transplant, autoimmune disorder treated with
steroids or immunosuppressive drug, lymphoma, leukemia or bone marrow transplant are
also ineligible (partners with these conditions are eligible)
We found this trial at
4
sites
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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1800 Orleans St.
Baltimore, Maryland 21287
410-955-5000
Johns Hopkins Hospital Patients are the focus of everything we do at The Johns Hopkins...
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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New York, New York 10029
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New York, NY
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