Pilot Study of the Rotavirus Vaccine in Infants With Intestinal Failure

Inclusion Criteria:

- Infants with one of the following diagnoses:

- necrotizing enterocolitis requiring operation;

- congenital atresia of the intestine;

- gastroschisis;

- midgut volvulus requiring bowel resection; or

- long-segment intestinal aganglionosis

- Minimum gestational age of 35 weeks at time of first vaccine dose

Exclusion Criteria:

- immunocompromise secondary to HIV infection or immunodeficiency state

- active use of corticosteroid or other immunosuppressive agents

- active infection as defined by fever > 38°C within 24 hours, positive blood culture
within 7 days, or positive urine culture within 3 days of enrollment

- severe malnutrition as defined by serum albumin < 2.0 mg/dL or serum prealbumin < 6
mg/dL.