Alopecia Areata Registry and Immunogenetic Mechanisms
| Status: | Completed |
|---|---|
| Conditions: | Dermatology, Hair Loss |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 5/3/2014 |
| Start Date: | September 2001 |
| End Date: | December 2014 |
| Contact: | Maria Hordinsky, MD |
| Email: | hordi001@umn.edu |
| Phone: | 612-625-1493 |
The goals of this study are to understand the genetic control of autoimmunity in alopecia
areata (AA), to better understand the complex biology of the cycling hair follicle, and to
use this knowledge to devise safe and effective treatments for this common disease.
areata (AA), to better understand the complex biology of the cycling hair follicle, and to
use this knowledge to devise safe and effective treatments for this common disease.
The purpose of this registry is to collect patient epidemiology data as well as to provide
samples that can be used for understanding the pathogenesis of AA, especially related to its
genetic basis as a complex trait. There are three ways one can assess which genes are
important: association studies in unrelated individuals, identify by descent in sib-pairs,
and linkage or transmission by descent in multiplex families.
samples that can be used for understanding the pathogenesis of AA, especially related to its
genetic basis as a complex trait. There are three ways one can assess which genes are
important: association studies in unrelated individuals, identify by descent in sib-pairs,
and linkage or transmission by descent in multiplex families.
Inclusion Criteria:
- All patients with AA, children and adults, who have been diagnosed by a
dermatologist, who is an expert in the field of alopecia. Subtypes that are
allowable are alopecia universalis, alopecia totalis, patchy persistent alopecia or
transient mild alopecia.
- Family members, related by blood, of these patients (preferably sib-pairs plus
parents and multiplex families).
- Age matched controls from spouses or clinic patients
Exclusion Criteria:
- A person under the age of 18 years not accompanied by parent or guardian.
- A person who is unable to comprehend the informed consent and sign the consent form.
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