A Study Of Inotuzumab Ozogamicin Plus Rituximab For Relapsed/Refractory Aggressive Non-Hodgkin Lymphoma Patients Who Are Not Candidates For Intensive High-Dose Chemotherapy



Status:Terminated
Conditions:Lymphoma, Psychiatric
Therapuetic Areas:Oncology, Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:1/10/2019
Start Date:April 4, 2011
End Date:March 28, 2014

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Trial Summary
Trial Overview
Inclusion Criteria

AN OPEN-LABEL, RANDOMIZED, PHASE 3 STUDY OF INOTUZUMAB OZOGAMICIN ADMINISTERED IN COMBINATION WITH RITUXIMAB COMPARED TO DEFINED INVESTIGATOR'S CHOICE THERAPY IN SUBJECTS WITH RELAPSED OR REFRACTORY CD22-POSITIVE AGGRESSIVE NON-HODGKIN LYMPHOMA WHO ARE NOT CANDIDATES FOR INTENSIVE HIGH-DOSE CHEMOTHERAPY

The purpose of this study is to evaluate the efficacy of inotuzumab ozogamicin plus rituximab
in relapsed/refractory aggressive Non-Hodgkin lymphoma patients who are not candidates for
intensive high-dose chemotherapy. Specifically, the goal is to demonstrate the superiority of
this combination compared with an active comparator arm (investigator's choice of
rituximab+bendamustine or rituximab+gemcitabine) using the primary endpoint of overall
survival.


Inclusion Criteria:

Exclusion Criteria:
We found this trial at
78
sites
Peggy and Charles Stephenson Cancer Center (clinic location)
Oklahoma City, Oklahoma 73104
?
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from 91732
Oklahoma City, OK
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Baylor University Medical Center
3500 Gaston Avenue
Dallas, Texas 75246
1.800.422.9567
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
1225
mi
from 91732
Dallas, TX
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Barbara Ann Karmanos Cancer Institute
4100 John R
Detroit, Michigan 48201
800-527-6266
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
1966
mi
from 91732
Detroit, MI
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Shands Hospital at the University of Florida
Gainesville, Florida 32610
2103
mi
from 91732
Gainesville, FL
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Baptist Medical Center
Jacksonville, Florida 32207
2131
mi
from 91732
Jacksonville, FL
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Advanced Medical Specialties
8940 N Kendall Dr # 300E
Miami, Florida 33176
2316
mi
from 91732
Miami, FL
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Beth Israel Med Ctr
305 1st Avenue # Dazian 7
New York, New York 10003
(212) 420-2806
Beth Israel Med Ctr The physicians and staff of Mount Sinai Beth Israel's Heart Institute...
2433
mi
from 91732
New York, NY
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St Luke's - Roosevelt Hospital Center
1111 Amsterdam Ave
New York, New York 10025
(212) 523-4000
St Luke's - Roosevelt Hospital Center With 523 beds, Mount Sinai St. Luke's serves as...
2434
mi
from 91732
New York, NY
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Georgia Regents Medical Cancer Pharmacy
Augusta, Georgia 30912
?
mi
from 91732
Augusta, GA
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Augusta University
1120 15th Street
Augusta, Georgia 30912
(706) 721-0211
Georgia Regents University Georgia Regents University, home of the Medical College of Georgia, is one...
2059
mi
from 91732
Augusta, GA
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Mount Sinai Comprehensive Cancer Center, Aventura
Aventura, Florida 33180
2320
mi
from 91732
Aventura, FL
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University Cancer Institute, LLC
Boynton Beach, Florida 33426
2308
mi
from 91732
Boynton Beach, FL
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Disney Family Cancer Center at Providence St Joseph Medical Center
Burbank, California 91505
?
mi
from 91732
Burbank, CA
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Providence St. Joseph Medical Center
Burbank, California 91505
19
mi
from 91732
Burbank, CA
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The University Hospital
Cincinnati, Ohio 45219
1879
mi
from 91732
Cincinnati, OH
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Kootenai Cancer Center
Coeur d'Alene, Idaho 83814
941
mi
from 91732
Coeur d'Alene, ID
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Good Samaritan Hospital, Corvallis
Corvallis, Oregon 97330
779
mi
from 91732
Corvallis, OR
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Samaritan Ambulatory Infusion Services
Corvallis, Oregon 97330
?
mi
from 91732
Corvallis, OR
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University Hospital - St. Paul
Dallas, Texas 75235
?
mi
from 91732
Dallas, TX
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University Hospital - Zale Lipshy
Dallas, Texas 75235
?
mi
from 91732
Dallas, TX
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Baylor Charles A Sammons Cancer Center
Dallas, Texas 75246
1224
mi
from 91732
Dallas, TX
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Simmons Comprehensive Cancer Center
Dallas, Texas 75390
1221
mi
from 91732
Dallas, TX
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Decatur Memorial Hospital (DMH)
Decatur, Illinois 62526
?
mi
from 91732
Decatur, IL
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Barbara Ann Karmanos Cancer Institute at farmington Hills
Farmington Hills, Michigan 48334
?
mi
from 91732
Farmington Hills, MI
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21st Century Oncology of Jacksonville, LLC
Fernandina Beach, Florida 32034
?
mi
from 91732
Fernandina Beach, FL
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Hematology-Oncology Medical Group of Fresno Inc
Fresno, California 93720
?
mi
from 91732
Fresno, CA
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Davis Cancer Pavilion and Shands Medical Plaza
Gainesville, Florida 32608
2105
mi
from 91732
Gainesville, FL
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Shands Cancer Hospital at the University of Florida
Gainesville, Florida 32608
2102
mi
from 91732
Gainesville, FL
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UF Health Davis Cancer Pavillion and Shands Med Plaza
Gainesville, Florida 32608
2102
mi
from 91732
Gainesville, FL
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UF Health Shands Cancer Hospital
Gainesville, Florida 32608
2104
mi
from 91732
Gainesville, FL
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UF Health Shands Hospital
Gainesville, Florida 32610
2104
mi
from 91732
Gainesville, FL
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Penn State Milton S. Hershey Medical Center
500 University Dr
Hershey, Pennsylvania 17033
(717) 531-6955
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
2296
mi
from 91732
Hershey, PA
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University of Texas M.D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
1357
mi
from 91732
Houston, TX
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21st Century Oncology of Jacksonville, Inc.
Jacksonville, Florida 32034
2134
mi
from 91732
Jacksonville, FL
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Baptist Cancer Institute
Jacksonville, Florida
2130
mi
from 91732
Jacksonville, FL
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University of Kansas Medical Center
3901 Rainbow Blvd
Kansas City, Kansas 66160
(913) 588-5000
University of Kansas Medical Center The University of Kansas Medical Center serves Kansas through excellence...
1332
mi
from 91732
Kansas City, KS
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Thompson Oncology Group
1915 White Avenue
Knoxville, Tennessee 37916
1922
mi
from 91732
Knoxville, TN
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Medical Specialists Of Palm Beaches
Lake Worth, Florida 33467
2300
mi
from 91732
Lake Worth, FL
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Universitaire Ziekenhuizen Leuven
Leuven, Vlaams Brabant
?
mi
from 91732
Leuven,
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University of Kentucky A.B. Chandler Medical Center
Lexington, Kentucky 40536
?
mi
from 91732
Lexington, KY
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University of Kentucky, Markey Cancer Center
Lexington, Kentucky
1881
mi
from 91732
Lexington, KY
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Southeast Nebraska Hematology & Oncology Consultants, P.C. d/b/a Southeast Nebraska Cancer Center
Lincoln, Nebraska 68510
1258
mi
from 91732
Lincoln, NE
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Ronald Reagan UCLA Medical Center, Drug Information Center, Department of Pharmaceutical Services
Los Angeles, California 90095
13
mi
from 91732
Los Angeles, CA
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Clinical Research Unit
Los Angeles, California 90024
13
mi
from 91732
Los Angeles, CA
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Peter Morton Medical Plaza
Los Angeles, California 90095
?
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Los Angeles, CA
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Ronald Reagan UCLA Medical Center
Los Angeles, California 90095
25
mi
from 91732
Los Angeles, CA
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Thompson Oncology Group
Maryville, Tennessee 37804
?
mi
from 91732
Maryville, TN
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Mercy Hospital
Miami, Florida 33133
2320
mi
from 91732
Miami, FL
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Mercy Research Institute
Miami, Florida
2320
mi
from 91732
Miami, FL
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Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida 33140
2324
mi
from 91732
Miami Beach, FL
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Mount Sinai Medical Center
Miami Beach, Florida 33140
2324
mi
from 91732
Miami Beach, FL
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Floyd Memorial Cancer Center of Indiana
New Albany, Indiana 47150
1809
mi
from 91732
New Albany, IN
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Tulane University Hospital & Clinic
New Orleans, Louisiana 70112
1655
mi
from 91732
New Orleans, LA
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Beth Israel Comprehensive Cancer Center
New York, New York
2432
mi
from 91732
New York, NY
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Memorial Sloan Kettering Cancer Center
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
2434
mi
from 91732
New York, NY
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Samaritan Pacific Coast Hospital
Newport, Oregon 97365
?
mi
from 91732
Newport, OR
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OU Medical Center Presbyterian Professional Building
Oklahoma City, Oklahoma 73104
?
mi
from 91732
Oklahoma City, OK
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OU Medical Center Presbyterian Tower
Oklahoma City, Oklahoma 73104
1165
mi
from 91732
Oklahoma City, OK
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Peggy and Charles Stephenson Cancer Center (chemo & infusion)
Oklahoma City, Oklahoma 73104
?
mi
from 91732
Oklahoma City, OK
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21st Century Oncology of Jacksonville, LLC
Orange Park, Florida 32073
?
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from 91732
Orange Park, FL
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Kootenai Cancer Center
Post Falls, Idaho 83854
944
mi
from 91732
Post Falls, ID
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Barnes Jewish Hospital
Saint Louis, Missouri 63110
1569
mi
from 91732
Saint Louis, MO
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Washington University in St. Louis
Saint Louis, Missouri 63110
1568
mi
from 91732
Saint Louis, MO
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Washington University
Saint Louis, Missouri 63110
1568
mi
from 91732
Saint Louis, MO
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
1569
mi
from 91732
Saint Louis, MO
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Park Nicollet Frauenshuh Cancer Center
Saint Louis Park, Minnesota 55426
1503
mi
from 91732
Saint Louis Park, MN
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Barnes-Jewish St. Peters
Saint Peters, Missouri 63376
?
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from 91732
Saint Peters, MO
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Sansum Clinic
Santa Barbara, California 93105
102
mi
from 91732
Santa Barbara, CA
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UCLA Santa Monica Hematology-Oncology
Santa Monica, California 90404
27
mi
from 91732
Santa Monica, CA
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Guthrie Clinic, Ltd.
Sayre, Pennsylvania 18840
2299
mi
from 91732
Sayre, PA
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Robert Packer Hospital
Sayre, Pennsylvania 18840
2299
mi
from 91732
Sayre, PA
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Thompson Oncology Group
Sevierville, Tennessee 37862
?
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from 91732
Sevierville, TN
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Sansum Clinic
Solvang, California 93463
126
mi
from 91732
Solvang, CA
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Stony Brook University Medical Center Cancer Center
Stony Brook, New York 11794
2477
mi
from 91732
Stony Brook, NY
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Stony Brook University Medical Center
101 Nicolls Rd
Stony Brook, New York 11794
(631) 444-4000
Stony Brook University Medical Center Stony Brook Medicine expresses our shared mission of research, clinical...
2503
mi
from 91732
Stony Brook, NY
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Howard University Hospital
Washington, District of Columbia 20060
2281
mi
from 91732
Washington,
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West Chester Hospital Medical Building
West Chester, Ohio 45069
1885
mi
from 91732
West Chester, OH
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University of Kansas Cancer Center and Medical Pavilion
Westwood, Kansas 66205
1338
mi
from 91732
Westwood, KS
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