An Inpatient Study Of The Efficacy, Safety, And Tolerability Of PF-02545920 In The Treatment Of Acute Exacerbation Of Schizophrenia



Status:Completed
Conditions:Schizophrenia
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:18 - 65
Updated:5/24/2018
Start Date:October 2010
End Date:August 2011

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A Phase 2, Multicenter, Double-blind, Randomized, Parallel Group, 4-week Inpatient Study To Evaluate The Safety And Efficacy Of Two Fixed Doses Of Pf-02545920 Compared To Placebo In The Treatment Of Acute Exacerbation Of Schizophrenia Using Risperidone As An Active Control

This study aims to evaluate whether PF-02545920 is safe and effective in the treatment of
acute exacerbation of schizophrenia during a 4-week inpatient treatment period. The study
will use the Positive and Negative Syndrome Scale (PANSS) to measure change in symptoms for
PF-02545920 compared to risperidone and placebo treatment.


Inclusion Criteria:

- Diagnosis of schizophrenia with acute exacerbation of illness

- The current acute exacerbation of schizophrenia must be less than 4 weeks duration
prior to the initial evaluation.

Exclusion Criteria:

- Subjects with evidence or history of clinically significant uncontrolled medical
illness

- Subjects with a current diagnosis of schizoaffective disorder, major depression,
bipolar disorder, or obsessive compulsive disorder.

- Subjects who meet Diagnostic and Statistical Manual-IV (DSM-IV)defined diagnostic
criteria for psychoactive substance dependence (excluding nicotine dependence) within
12 months of screening or DSM-IV defined substance abuse within 3 months prior to
screening.
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Rockville, Maryland 20850
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Anaheim, California 92801
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811 Juniper St NE
Atlanta, Georgia 30308
(404) 881-5800
Atlanta Center for Medical Research Welcome to the Atlanta Center for Medical Research, a leader...
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Austin, Texas 78731
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Austin, Texas 78745
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Austin, Texas 78754
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8043 Cooper Creek Boulevard Suite 107
Bradenton, Florida 34201
(941) 747-7900
Florida Clinical Research Center, LLC Led by Andrew J. Cutler, M.D., Florida Clinical Research Center,...
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DeSoto, Texas 75115
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Escondido, California 92025
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Escondido, California 92025
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Garden Grove, California 92845
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Hoffman Estates, Illinois 60169
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Hoffman Estates, Illinois 60169
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1786 Moon Lake Boulevard
Hoffman Estates, Illinois 60169
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88 Park Avenue
Hollis, New York 11423
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Houston, Texas 77024
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5314 Dashwood Drive
Houston, Texas 77081
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Kirkland, Washington 98033
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10200 Northeast 132nd Street
Kirkland, Washington 98034
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Lake Charles, Louisiana 70601
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Lake Charles, Louisiana 70601
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Little Rock, Arkansas 72201
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Long Beach, California 90806
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Long Beach, California 90822
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Maitland, Florida 32751
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101 The City Drive South
Orange, California 92868
714-456-7890
University of California, Irvine Medical Center We are UC Irvine Health. We are a devoted...
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434 West Kennedy Boulevard
Orlando, Florida 32810
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Paramount, California 90723
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8835 Vans Street
Paramount, California 90723
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Philadelphia, Pennsylvania 19139
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10330 Old Olive Street Road
Saint Louis, Missouri 63141
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San Diego, California 92123
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Washington, District of Columbia 20016
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Willingboro, New Jersey 08046
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218 Sunset Road
Willingboro, New Jersey 08046
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