Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS)



Status:Recruiting
Conditions:Irritable Bowel Syndrome (IBS), Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:5 - Any
Updated:3/22/2019
Start Date:June 2003
End Date:December 2022
Contact:Lisa Datta, MS
Email:ibd@jhu.edu
Phone:410-502-0040

Use our guide to learn which trials are right for you!

The investigators are doing the research to discover genes that cause Inflammatory Bowel
Disease (IBD) specifically in the African American population. African Americans with or
without Crohn's disease or ulcerative colitis are eligible to join. If you agree to join the
study, the investigators will ask for information about your health. The investigators will
also ask you to give us a blood sample so that they may discover the genes that cause IBD.
The blood sample may be collected at Johns Hopkins or any local facility convenient to you.

This current protocol was established as part of an NIDDK initiative to further explore
genetic factors associated with IBD. Specifically, the investigators are interested in
identifying the genetic, environment and socio-economical components that contribute to the
development of IBD in the African American population.

IBD is believed to be caused by a combination of environmental and genetic factors. Genetic
data will be examined alongside potential environmental factors such as smoking, medications,
environmental exposures, and some dietary factors. Since IBD is known to predominantly affect
Western, industrialized areas of the world, the investigators will also inquire about
participants' socioeconomic background in hopes of identifying any previously unknown factors
in the AA population that may increase the risk of IBD. These potential environmental factors
will be important in association analyses using covariates as these factors can obscure
potential associations or interact with genetic factors and thus contribute to genetic
associations. The investigators will also obtain information as to ancestry of parents and
grandparents as to best match cases with unrelated controls of similar ancestry (e.g.,
Caribbean, recent European or recent African ancestry could cause genetic mismatch of a case
and control). At the same time, the investigators will also collect similar information
(smoking, medications, environmental exposures and dietary factors) from non-African
Americans for the purpose of making direct comparisons for these parameters between the
different racial groups to assess the contribution of non-genetic factors for susceptibility
to the development of IBD.

This study calls for recruiting AA patients and ethnically matched controls (friend or
spouse). These persons will provide us with a blood sample and with information requested on
a questionnaire asking the following: clinical course and history of their IBD or their
general health, smoking history, socioeconomic variables and specific dietary factors known
in some populations to be related to IBD etiology. Access to medical records will be used to
confirm diagnoses. The clinical characteristics of IBD obtained from medical records will be
summarized in a phenotyping form using a standardized NIDDK IBDGC Phenotyping Operations
Manual. Controls will be asked health history to identify potentially unrecognized IBD. DNA
and other biospecimens will be purified from blood. Samples and data will also be shared with
the NIDDK IBDGC for use in IBDGC research projects and will be processed and maintained at
NIDDK repositories.

Inclusion Criteria:

1. African Americans with a confirmed diagnosis of Inflammatory Bowel Disease (IBD)

2. African Americans without a diagnosis of IBD and without a family history of IBD for
comparison purposes

Exclusion Criteria: Patients whose IBD cannot be confirmed
We found this trial at
10
sites
733 North Broadway
Baltimore, Maryland 21205
(410) 955-3182
Principal Investigator: Steven R Brant, MD
Phone: 410-502-0040
Johns Hopkins University School of Medicine Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is...
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Peter Mannon, MD
Phone: 205-934-0498
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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Chapel Hill, North Carolina 27599
(919) 962-2211
Principal Investigator: Kim Isaacs, MD
Phone: 919-843-9071
University of North Carolina at Chapel Hill Carolina’s vibrant people and programs attest to the...
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Chapel Hill, NC
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Principal Investigator: Joel Pekow, MD
Phone: 773-834-7414
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
Principal Investigator: Jason K Hou, MD
Phone: 713-798-7616
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
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Houston, TX
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Baltimore, Maryland 21201
Principal Investigator: Howard Kader, MD
Phone: 410-328-4055
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Baltimore, MD
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500 S Preston St
Louisville, Kentucky
(502) 852-5555
Principal Investigator: Gerald Dryden, MD
Phone: 502-852-1919
University of Louisville The University of Louisville is a state supported research university located in...
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Louisville, KY
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New Brunswick, New Jersey 08901
Principal Investigator: Steven R Brant, MD
Phone: 732-235-3241
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New Brunswick, NJ
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New York, New York 10021
Principal Investigator: Ellen Scherl, MD
Phone: 212-746-5109
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New York, NY
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Richmond, Virginia 23298
(804) 828-0100
Principal Investigator: Jay F Kuemmerle, MD
Phone: 804-828-8239
Virginia Commonwealth University Since our founding as a medical school in 1838, Virginia Commonwealth University...
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Richmond, VA
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