Myocardial Ischemia and Transfusion Pilot



Status:Completed
Conditions:Angina, Peripheral Vascular Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:3/22/2019
Start Date:September 2009
End Date:June 2012

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The purpose of this study is to evaluate two approaches to red blood cell transfusion in
anemic patients with acute coronary syndrome.

Red blood cell transfusions are extremely common medical interventions, yet, it remains
unclear when patients should be transfused. This pilot study will evaluate the feasibility of
conducting a research protocol that will lead to a large scale clinical trial designed to
evaluate the treatment effectiveness of two transfusion threshold strategies in patients with
coronary artery disease.

Inclusion Criteria:

- age 18 or older;

- STEMI (ST segment elevated myocardial infarction)

- NSTEMI (Non ST segment elevation myocardial infarction)

- unstable angina

- stable coronary artery disease (undergoing cardiac catheterization during the index
hospitalization);

- written informed consent has been obtained

- hemoglobin concentration less than 10 g/dL at the time of random allocation.

Exclusion Criteria:

- bleeding cannot be controlled at the cardiac catheterization puncture site and/or
require surgery to repair vessel

- retroperitoneal bleeding requiring surgery

- clinically important hemodynamic instability based on the judgment of the treating
physician

- terminal malignancy or life expectancy less than 6 months

- scheduled for cardiac surgery within the next 30 days

- symptomatic at the time of randomization

- declines blood transfusion

- history of a clinically significant transfusion reaction

- inability to provide informed consent;

- enrolled in a competing study

- previous participation in the MINT trial

- any patient who in the judgment of the research team should not be enrolled in the
trial. This would include, but not be limited to, factors such alcohol or drug
dependence, or psychiatric illness.
We found this trial at
7
sites
200 Lothrop St
Pittsburgh, Pennsylvania 15213
University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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Boston, MA
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3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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Bronx, NY
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593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Providence, RI
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New Brunswick, New Jersey 08903
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New Brunswick, NJ
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New York, NY
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Pittsburgh, Pennsylvania 15261
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Pittsburgh, PA
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