Eicosapentaenoic Acid and Protein Modulation to Induce Anabolism in Chronic Obstructive Pulmonary Disease(COPD): Aim 1
| Status: | Archived |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | May 2009 |
| End Date: | May 2012 |
Eicosapentaenoic Acid and Protein Modulation to Induce Anabolism in COPD: Aim 1
Cachectic COPD patients are characterized by a decreased muscle protein synthesis and an
elevated myofibrillar protein breakdown. A substantial number of these patients,
characterized by an enhanced systemic inflammatory response, failed to respond to
nutritional therapy, which is of clinical relevance as weight gain to nutritional therapy is
a significant, independent predictor of mortality in COPD. It is the investigators
hypothesis that a nutritional supplement containing casein protein and high levels of
leucine will target the metabolic alterations of these cachectic COPD patients and will
specifically stimulate protein anabolism. In the present study, the acute effects of casein
vs. whey protein and the effects of adding leucine on whole body, and muscle protein
metabolism will be examined in COPD patients with severe loss of muscle mass. The principal
endpoints will be the extent of stimulation of whole body protein synthesis as this is the
principal mechanism by which either amino acid or protein intake causes muscle anabolism.
In the present proposal, the effect of different proteins in COPD will be examined by
comparing oral supplements containing either whey or casein hydrolysate. Furthermore the
effects of protein feeding with or without enrichment of leucine will be investigated.
Variables of interest are: 1. Net whole body protein synthesis; 2. Whole body protein
synthesis and breakdown rate, whole body myofibrillar protein breakdown rate, whole body
collagen breakdown, kinetics of insulin, glucose, and amino acid levels.
In the present study we propose that a casein protein supplement will stimulate protein
anabolism to a greater extent than whey protein supplement and adding leucine to it will be
of additional benefit in COPD patients with muscle wasting. The knowledge gained from this
study will benefit our insight in terms of promotion of protein anabolism in COPD patients.
The long-term goal is to reformulate nutritional composition in accord with the effects of
COPD on protein metabolism in order to ameliorate or even prevent progressive muscle wasting
in these subjects, and improve their quality of life and survival rates.
We found this trial at
1
site
529 West Markham Street
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
(501) 686-7000
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
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