Genetic Modifiers of Cystic Fibrosis Related Diabetes

Conditions:Pulmonary, Diabetes
Therapuetic Areas:Endocrinology, Pulmonary / Respiratory Diseases
Age Range:Any - 99
Start Date:April 2008
End Date:April 2020

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This research is being done to find the genes and other factors that are responsible for
differences among persons with cystic fibrosis. We are particularly interested in the factors
that relate to the development of Cystic Fibrosis Related Diabetes (CFRD).

The study is recruiting people with cystic fibrosis (CF). The medical record is being
extracted, and a blood sample is taken for DNA. The DNA samples are tested for variation both
at the CFTR gene (the CF gene) and over the entire rest of the genome. Using large numbers of
people with CF, and knowing who does and does not have CFRD, we identify genetic variations
that associate with CFRD. Knowing these variations allows us to better understand the causes
of CFRD, and with enough information, better to predict CFRD and identify people at
particularly high or low risk of CFRD. People participating in this study also have the
option to participate in related studies of other metabolic traits in CF such as over- and

Inclusion Criteria:

- Any person with Cystic Fibrosis and his/her parents.

Exclusion Criteria:
We found this trial at
Chicago, Illinois 60614
Chicago, IL
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Minneapolis, Minnesota 55455
(612) 625-5000
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
Minneapolis, MN
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Baltimore, Maryland 21231
Phone: 410-955-6463
Baltimore, MD
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