PF-00489791 For The Treatment Of Raynaud's
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 5/18/2018 |
| Start Date: | August 4, 2010 |
| End Date: | May 31, 2011 |
A Phase 2a Randomized Double-blinded, Placebo And Active Controlled Two Cohort Two Doses Cross-over Multi-center Clinical Study To Assess Efficacy Of A Once Daily Administration Of A Phosphodiesterase 5 Inhibitor (Pf-00489791) For The Treatment Of Vasospasm In Primary And Secondary Raynaud's Phenomenon
The investigators propose that once daily administration of PF-00489791, a phosphodiesterase
inhibitor, will reduce vasospasm and improve symptoms and signs associated with Primary and
Secondary Raynaud's Phenomenon.
inhibitor, will reduce vasospasm and improve symptoms and signs associated with Primary and
Secondary Raynaud's Phenomenon.
Inclusion Criteria:
- Active Raynaud's Phenomenon
- Stable disease and medication requirements over the previous two months
- For Secondary Raynaud's Phenomenon subjects, a diagnosis of scleroderma using the
American College of Rheumatology criteria or by the presence of at least 3/5 features
of CREST syndrome
- both sexes
Exclusion Criteria:
- Uncontrolled hypertension, diabetes mellitus, angina, or using oral nitrates
- Smoking within 3 months or smoking cessation using nicotine products
- Subjects currently taking sildenafil, tadalafil or vardenafil
- Subjects with ulnar arterial occlusive disease as shown by a modified Allen test
- Pregnant or breast feeding or considering pregnancy in next 4 months
- Participation in trial for investigational drug within 30 days
We found this trial at
24
sites
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University of Michigan The University of Michigan was founded in 1817 as one of the...
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1500 E Medical Center Dr
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health System The University of Michigan is home to one of the...
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263 Farmington Ave
Farmington, Connecticut 06030
Farmington, Connecticut 06030
(860) 679-2000
University of Connecticut Health Center UConn Health is a vibrant, integrated academic medical center that...
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South Bend, Indiana 46601
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3800 Reservoir Rd NW
Washington, District of Columbia 20007
Washington, District of Columbia 20007
(202) 444-2000
Georgetown University Hospital MedStar Georgetown University Hospital is a not-for-profit, acute-care teaching and research hospital...
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