Frozen Red Blood Cell Transfusions in Trauma Patients



Status:Completed
Conditions:Hospital, Anemia
Therapuetic Areas:Hematology, Other
Healthy:No
Age Range:15 - 100
Updated:4/6/2019
Start Date:January 2010
End Date:May 2014

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Efficacy and Safety of Frozen Red Blood Cells for Transfusion in Trauma Patients

The purpose of this study is to look at red blood cell (RBC) transfusions in trauma patients
and evaluate for any differences between the age of the RBCs and how they were stored. The
investigators will specifically look for the following differences between study groups:

1. the transfused red blood cells' ability to delivery oxygen to the tissues

2. differences in biochemical markers in subjects and units transfused, and

3. how the subject's internal organs are working and if they develop any infections


Inclusion Criteria:

- Trauma Service with an Injury Severity Score > 4

- Require a blood (PRBC) transfusion

- Transfusion is not emergent

- Able to obtain consent from patient or appropriate 3rd party prior to 1st transfusion

Exclusion Criteria:

- Inability to adhere to blood age randomization due to limitations of the blood bank
inventory

- Bilateral hand injuries that prevent StO2 measurements

- Age < 15

- Pregnancy

- Massive transfusion (=/> 10 units in 24 hours) in last 3 months

- Hemodynamically unstable or need for transfusion in < 3 hours
We found this trial at
5
sites
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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7000 Fannin St
Houston, Texas 77030
(713) 500-4472
University of Texas Health Science Center at Houston The University of Texas Health Science Center...
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Houston, TX
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4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
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San Antonio, TX
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2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
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Cincinnati, OH
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1801 Inwood Rd
Dallas, Texas 75390
(214) 645-3300
University of Texas Southwestern Medical Center UT Southwestern is an academic medical center, world-renowned for...
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Dallas, TX
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