Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases
| Status: | Recruiting |
|---|---|
| Conditions: | Blood Cancer, Endocrine, Hematology |
| Therapuetic Areas: | Endocrinology, Hematology, Oncology |
| Healthy: | No |
| Age Range: | Any - 20 |
| Updated: | 5/9/2018 |
| Start Date: | December 2001 |
| End Date: | December 2021 |
| Contact: | Lisa Murray, MA, CCRP |
| Email: | Murray_L@kids.wustl.edu |
| Phone: | 3144544240 |
A Study of Hematopoietic Stem Cell Transplantation (HSCT) in Non-Malignant Disease Using a Reduced-Intensity Preparatory Regime
The hypothesis for this study is that a preparative regimen that maximizes host
immunosuppression without myeloablation will be well tolerated and sufficient for engraftment
of donor hematopoietic cells. It is also to determine major toxicities from these
conditioning regimens, within the first 100 days after transplantation.
immunosuppression without myeloablation will be well tolerated and sufficient for engraftment
of donor hematopoietic cells. It is also to determine major toxicities from these
conditioning regimens, within the first 100 days after transplantation.
Inclusion Criteria:
Stratum 1: Patient must have a hemoglobinopathy receiving a matched related transplant with
bone marrow or peripheral blood stem cells.
Stratum 2: Patient must have thalassemia receiving an unrelated donor transplant with bone
marrow or umbilical cord blood stem cells.
Stratum 3: Patient must have a hemoglobinopathy receiving a minimally mismatched unrelated
donor transplant with bone marrow or single or double umbilical cord blood product.
Stratum 4: Patient must have a non-malignant disorder (excluding hemoglobinopathy)
receiving a minor mismatched unrelated donor transplant with bone marrow or single or
double umbilical cord blood product.
All strata:
- Recipient age < 21 years
- Lansky/Karnofsky >/= 40
- Adequate pulmonary, renal, liver, and other organ function as defined in protocol
- Negative pregnancy test
- Adequate total nucleated cell or CD34+ dose of product as defined in protocol
- If sickle cell, Hemoglobin S <45%
Exclusion Criteria:
- HIV positive
- Invasive infection
- Pregnancy/lactating
We found this trial at
18
sites
630 W 168th St
New York, New York
New York, New York
212-305-2862
Principal Investigator: Monica Bhatia, MD
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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1000 Blythe Blvd
Charlotte, North Carolina 28203
Charlotte, North Carolina 28203
(704) 355-2000
Principal Investigator: Michael Eckrich, MD
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Miami, Florida 33124
(305) 284-2211
Principal Investigator: Martin Andreansky, MD
University of Miami A private research university with more than 15,000 students from around the...
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3100 SW 62nd Ave
Miami, Florida 33155
Miami, Florida 33155
(305) 666-6511
Principal Investigator: Kamar Godder, MD
Miami Children's Hospital Welcome to Miami Children
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2301 Erwin Rd
Durham, North Carolina 27710
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Suhag Parikh, MD
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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30 Prospect Ave
Hackensack, New Jersey 07601
Hackensack, New Jersey 07601
(201) 996-2000
Principal Investigator: Alfred Gillio, MD
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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340 W 10th St #6200
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
(317) 274-3772
Principal Investigator: Paul Haut, MD
Indiana University School of Medicine With more than 2,000 students in 2013, the Indiana University...
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Kansas City, Missouri 64108
Principal Investigator: Jignesh Dalal, MD
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1919 E Thomas Rd
Phoenix, Arizona 85006
Phoenix, Arizona 85006
(602) 933-1000
Principal Investigator: Roberta Adams, MD
Phoenix Children's Hospital Phoenix Children's Hospital has provided hope, healing, and the best healthcare for...
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660 South Euclid Avenue
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
Phone: 314-454-6018
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Washington, District of Columbia 20037
Principal Investigator: David Jacobsohn, MD
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