Biomarkers in Patients With Head and Neck Cancer and in Healthy Volunteers



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/2/2016
Start Date:April 2005

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Serum Biomarkers for Head and Neck Cancer

RATIONALE: Studying samples of blood, tissue, and saliva in the laboratory from patients
with cancer and from healthy volunteers may help doctors identify and learn more about
biomarkers related to cancer.

PURPOSE: This laboratory study is looking at biomarkers in patients with head and neck
cancer and in healthy volunteers.

OBJECTIVES:

- Correlate the differences in serum protein profiles with the differences in the number
of peptide matches in patients with squamous cell carcinoma of the head and neck and in
healthy volunteers.

- Correlate protein levels with the largest difference in peptide matches in sera in
these participants.

OUTLINE: This is a prospective study.

Participants undergo blood, tissue, and saliva collection for biological studies. Samples
are analyzed for albumin-bound and non-albumin-bound proteins or IgG via liquid
chromatography and tandem mass spectrometry (LC-MS-MS), ELISA, proteomic profiling, and
protein expression.

PROJECTED ACCRUAL: A total of 50 patients and 50 healthy volunteers will be accrued for this
study.

DISEASE CHARACTERISTICS:

- Meets one of the following criteria:

- Diagnosis of squamous cell carcinoma of the head and neck

- Healthy volunteer matched by sex, race, birth decade, or smoking status (e.g.,
current smoker, former smoker, or nonsmoker)

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified
We found this trial at
3
sites
2107 Edward Curd Lane
Nashville, Tennessee 37067
615-591-9890
Vanderbilt-Ingram Cancer Center at Franklin The Vanderbilt-Ingram Cancer Center at Franklin is a free-standing radiation...
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Nashville, TN
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2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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Nashville, TN
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324 Cool Springs Blvd
Nashville, Tennessee 37067
(877) 936-8422
Vanderbilt-Ingram Cancer Center - Cool Springs Vanderbilt-Ingram Cancer Center Cool Springs is a medical oncology...
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Nashville, TN
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