Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer

Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Age Range:18 - Any
Start Date:December 2003
End Date:January 31, 2025
Contact:Vanderbilt Ingram Clinical Trials Information Program

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Molecular Predictors of Lung Cancer Behavior

RATIONALE: Using samples of blood, urine, sputum, and lung tissue from patients at high risk
of cancer for laboratory studies may help doctors learn more about changes that may occur in
DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at molecular predictors of cancer in patients at high
risk of lung cancer.


- To use fixed lung tissue for histological evaluation and fresh tissue samples for
molecular studies to study DNA, RNA, and protein abnormalities in lung preneoplastic and
neoplastic lesions.

- To use proteomic techniques, including matrix-assisted laser desorption ionization-mass
spectrometry (MALDI-MS), to develop a method of diagnosing and staging both pre-invasive
and invasive lesions, using less invasive methods.

OUTLINE: Blood, urine, nasal cell, and sputum samples are collected. Lung tissue samples are
also collected using fluorescence bronchoscopy and epithelial cell collection.

Samples are studied by genetic and proteomic analyses, including comparative genomic
hybridization, expression microarray, and protein profiling.

Inclusion Criteria:

-All adults referred to Vanderbilt Medical Center, Veterans Administration Medical Center,
St. Thomas Hospital and Meharry Medical Center for evaluation of signs or symptoms of lung

Exclusion Criteria:

- Inability to provide informed consent

- Minors

- Pregnant women
We found this trial at
2220 Pierce Ave
Nashville, Tennessee 37232
Principal Investigator: Pierre Massion, MD
Phone: 800-811-8480
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
Nashville, TN
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Nashville, Tennessee 37212
Principal Investigator: Pierre Massion, MD
Phone: 615-873-8066
Nashville, TN
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