Collecting and Analyzing Tissue Samples From Patients Undergoing Surgery for Non-Small Cell Lung Cancer



Status:Recruiting
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 120
Updated:8/26/2018
Start Date:May 2001
End Date:July 2025
Contact:VICC Clinical Trials Information Program
Phone:800-811-8480

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Molecular Fingerprinting of Lung Cancer

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that may occur in RNA and identify biomarkers related
to cancer.

PURPOSE: This research study is collecting and analyzing lung tissue samples from patients
undergoing surgery for non-small cell lung cancer.

OBJECTIVES:

- Develop statistical and computational methods for modeling the relationships between
multiple variable protein and RNA expression data and clinical endpoints using both
supervised and unsupervised classification and pattern recognition approaches.

- Determine protein and RNA expression fingerprints on completely resected non-small cell
lung cancer without prior chemotherapy.

- Correlate protein and RNA expression fingerprints with T-stage and nodal involvement at
the time of surgery, and collect outcome data to allow correlation with recurrence
(local and/or distant) and survival.

OUTLINE: This is a multicenter study.

Any excess tissues removed from surgery and would otherwise be discarded (tissues not used
for diagnosis and/or treatment decision making) are obtained for this study. Tissue are
analyzed for molecular features that predict biologic behavior. Quantitation of RNA, gene
expression profiles, and protein expression patterns are assessed by matrix-assisted laser
desorption/ionization time of flight mass spectroscopy and microarray analysis.

Medical records are reviewed to obtain information about results of tests associated with
cancer diagnosis. Further progress in cancer treatment and tumor behavior after surgery are
followed via record review.

Inclusion criteria

- Diagnosis of non-small cell lung cancer

- Clinical stage I and II disease

- Resectable disease and complete surgical resection planned

- Treated on companion studies at Vanderbilt University, the Veterans Administration
hospital, St. Thomas, and Vanderbilt-Ingram Cancer Center Affiliate Network

- Tumor specimen samples must be available at resection

Exclusion criteria

- Chemotherapy before surgery

- Radiotherapy before surgery
We found this trial at
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Nashville, Tennessee 37212
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2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Phone: 800-811-8480
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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324 Cool Springs Blvd
Nashville, Tennessee 37067
(877) 936-8422
Phone: 800-811-8480
Vanderbilt-Ingram Cancer Center - Cool Springs Vanderbilt-Ingram Cancer Center Cool Springs is a medical oncology...
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2107 Edward Curd Lane
Nashville, Tennessee 37067
615-591-9890
Phone: 800-811-8480
Vanderbilt-Ingram Cancer Center at Franklin The Vanderbilt-Ingram Cancer Center at Franklin is a free-standing radiation...
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Nashville, Tennessee 37205
Phone: 615-222-2166
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