NKTR-102 Versus Irinotecan in Patients With Second-Line, Irinotecan-Naïve, KRAS Mutant, Colorectal Cancer



Status:Recruiting
Conditions:Colorectal Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:5/5/2014
Start Date:December 2008
Contact:Robert Medve, MD
Phone:415-482-5300

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A Multicenter, Open-Label, Randomized, Phase 2 Study to Evaluate the Efficacy and Safety of NKTR-102 Versus Irinotecan in Patients With Second-Line, Irinotecan-Naive, KRAS-Mutant, Metastatic Colorectal Cancer (mCRC)

This study will evaluate whether NKTR-102, an investigational drug has an anti-tumor effect
in patients with colorectal cancer. This study will also evaluate how the safety and
anti-tumor activity of NKTR-102 compares with irinotecan, a cancer drug that is approved for
use in the US for treatment of patients with certain types of colorectal cancer.


Inclusion Criteria:

- metastatic colorectal cancer

- tumor with k-ras mutation

Exclusion Criteria:

- More than 1 prior regimen for treatment of metastatic disease
We found this trial at
9
sites
Vallejo, California 94589
365
mi
from 91732
Vallejo, CA
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4100 John R
Detroit, Michigan 48201
800-527-6266
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
1966
mi
from 91732
Detroit, MI
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Buffalo, New York 14215
2180
mi
from 91732
Buffalo, NY
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18
mi
from 91732
Burbank, CA
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Centralia, Illinois 62801
1630
mi
from 91732
Centralia, IL
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Knoxville, Tennessee 37909
1923
mi
from 91732
Knoxville, TN
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1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
11
mi
from 91732
Los Angeles, CA
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Louisville, Kentucky 40202
1812
mi
from 91732
Louisville, KY
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Peoria, Arizona 85381
333
mi
from 91732
Peoria, AZ
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