Treatment With Pazopanib for Neoadjuvant Breast Cancer



Status:Archived
Conditions:Breast Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:July 2009
End Date:October 2012

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A Phase II Clinical Trial of Four Cycles of Doxorubicin and Cyclophosphamide Followed by Weekly Paclitaxel Given Concurrently With Pazopanib as Neoadjuvant Therapy Followed by Postoperative Pazopanib for Women With Locally Advanced Breast Cancer


The purpose of this study is to determine whether the treatment of a doxorubicin in
combination with cyclophosphamide followed by a combination of pazopanib in combination with
paclitaxel prior to surgery results in a pathological complete response in females with
breast cancer.


This is a phase II non-randomized, multi-center study aimed to evaluate the efficacy and
safety of the combination of pazopanib and paclitaxel following treatment with
cyclophosphamide and doxorubicin for the treatment of neoadjuvant breast cancer.

Patients will receive standard doses of AC every 21 days for 4 cycles. This will be followed
by weekly paclitaxel 80 mg/m2 IV on Days 1, 8, and 15 every 28 days for 4 cycles given
concurrently with pazopanib 800 mg PO daily starting with the first paclitaxel dose and
continuing until 7 days before surgery. Clinical complete response rate will be determined
by tumor assessments performed by palpation at two time points: following AC (before
paclitaxel/pazopanib begins) and 2-4 weeks following the last dose of paclitaxel (before
surgery). Following recovery from preoperative therapy, patients will undergo the
clinically-indicated surgery. Pazopanib will resume 4-6 weeks after surgery and continue
daily for 6 months of postoperative pazopanib therapy.


We found this trial at
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Ames, Iowa 50010
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Providence, RI
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4000 Reservoir Road NW, Suite 120
Washington, Washington DC 20007
(202) 687-0100
Georgetown Univ Med Ctr Georgetown University Medical Center is committed to excellence in research, education...
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Washington, DC
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Anaheim, California 92807
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Anaheim, CA
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Aurora, Colorado 80010
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Aurora, CO
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Austin, Texas 78705
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Austin, TX
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Charleston, SC
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Cherry Hill, New Jersey 08003
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Cherry Hill, NJ
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Grand Rapids, Michigan 49546
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Grand Rapids, MI
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Kennewick, Washington 99336
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Kennewick, WA
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Klamath Falls, Oregon 97601
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Klamath Falls, OR
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La Crosse, Wisconsin 54601
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La Crosse, WI
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Louisville, Kentucky 40202
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Louisville, KY
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1 Medical Center Drive
Morgantown, West Virginia 26506
304-598-4800
West Virginia University Hospitals Inc. WVU Healthcare is two corporations, University Health Associates and WVU...
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Morgantown, WV
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333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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New Haven, CT
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722 W 168th St
New York, New York 10032
(212) 305-2500
Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
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Philadelphia, Pennsylvania 19104
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Philadelphia, PA
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Richmond, Virginia 23298
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Richmond, VA
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Roswell, Georgia 30076
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Roswell, GA
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